PTEN ser-unknown phosphorylatedPTEN ser-13 ser-289 phosphorylatedPTEN ser-289 phosphorylatedPTEN ser-40 ser-150 ser-326 phosphorylatedPTEN ser-40 ser-150 ser-326 ser-342 ser-344 ser-349 phosphorylatedPTEN ser-336 phosphorylatedPTEN ser-370 ser-380 ser-382 ser-383 ser-385 phosphorylatedPTEN ser-unknown phosphorylated [cytosol]PTEN ser-13 ser-289 phosphorylated [nucleoplasm]PolyUb-PTEN [cytosol]K27polyUb-PTEN [cytosol]
P279
PTEN:Mg2+PolyUb-TP53;PolyUb-MDM2;PolyUb-MDM4;PolyUb-FOXO4;PolyUb-PTENTP53;MDM2;MDM4;FOXO4;PTENPolyUb-PTEN; K48polyUb-K289-PTEN; PolyUb-K324;K344;K349-RibC-E40;E150;D326-PTENPolyUb-PTEN;K48polyUb-K289-PTENPTEN:p-Y387-FRKPTEN; p-3S;2T-PTENPTEN:TRIM27PTEN mRNA translation negatively regulated by microRNAsPTEN dephosphorylates PIP3PI(3;4)P2 is dephosphorylated to PI4P by PTEN at the plasma membraneOTUD3 deubiquitinates PTENPTEN mRNA translation is negatively regulated by microRNAsPTEN undergoes monoubiquitinationMonoubiquitinated PTEN translocates to the nucleusUSP7 deubiquitinates monoubiquitinated PTENDeubiquitinated PTEN translocates to the cytosolNEDD4; WWP2; CHIP and XIAP polyubiquitinate PTENMKRN1 polyubiquitinates PTENTNKS and TNKS2 PARylate PTENUSP13 and OTUD3 deubiquitinate PTENPTEN binds FRKCasein kinase II phosphorylates PTENTRIM27 binds PTENPTEN mRNA translation is inhibited by miR-137
P527
P688
The lipid phosphatase activity of PTEN is critical for its tumor supressor functionThe tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal regionThreonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ bindingEvidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2Phosphorylation of the PTEN tail regulates protein stability and functionPTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1Subcellular localization of intracellular protein tyrosine phosphatases in T cellsUbiquitination regulates PTEN nuclear import and tumor suppressionMAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cellsCancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein functionCritical role for Daxx in regulating Mdm2Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structuresNHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membraneTIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cellsPhosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalitiesTEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor betaThe tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateA comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromesPTEN regulation by Akt-EGR1-ARF-PTEN axisInhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENP-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseA family of putative tumor suppressors is structurally and functionally conserved in humans and yeastNuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent mannermiR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulationUpregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture modelDeubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesisElectric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activationTGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansionInvolvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell linesPPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21.The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress.
P921
Q50373592-CB724EB6-7B77-4CE6-B91B-A95CA7B0F6C2Q50374383-74028D6E-131F-434A-BEDD-7E631A90AE80Q50374386-977ECE99-28B3-40A5-96FC-C84C47B3FD49Q50374387-82701A5E-D5C8-4978-A90F-A4887F9B1E49Q50374388-F132AE5B-5244-4397-9B39-81D16E629036Q50374390-83431C8C-CBB5-43BD-BC3A-442CDA800C72Q50374391-1ED4FD52-5E24-4262-B91B-BE2F9808DBF9Q50681595-24314AA7-EEAA-4D60-8045-21059E948ECEQ50682008-0AD404B2-C74A-42CD-BDB1-C932986F4C1EQ50687162-E274BEE9-4BCF-4C91-AB41-7DC6A15398DDQ50687163-E99F7433-5C82-443F-875B-239AACCA11F9
P279
Q50264484-ABC8C295-C60B-4010-9270-3509F6B5C9CCQ50268815-2AC0A56D-1182-4B51-A331-2DC2D810D234Q50268819-AA515220-C84A-41E3-830F-CA8C3C177394Q50274118-ADFD4257-7527-40B1-B303-08907A234B27Q50274119-6C50864D-F1B8-4E9F-94DC-433AA434DA22Q50274121-E3C12DA0-6882-4030-B138-83A5CF9F8EAEQ50274122-DDA7018C-C17E-4C09-A90E-D717E80F11AFQ50274124-88AB1FA7-7CB0-4151-990D-CBF8C309A3F1Q50290154-5FA9C909-739A-4A79-BFD4-2FE358866C83Q50291403-0DA26923-8BBD-4951-B328-2695981C124DQ50293924-6267F40C-A0FB-4F7A-9307-13597D7B8E8FQ50296561-0B43847C-1275-45A8-B187-F824749ADE37Q50299118-35085CE6-03F4-4D68-BEE3-CC05224AF80DQ50299133-F1447179-5F34-44D9-A605-F72BB6388A4DQ50299134-8E8FBC4C-87E4-4B57-A03B-A26FB4F968D2Q50299134-F6EDD74D-4602-4F27-9DD4-5ED251DA4530Q50299135-6896953E-ECCF-4EF2-AF43-119A5E54BF93Q50299136-274FEAB8-E6EC-4A09-9C5A-98063C0B9AC6Q50299136-FA5775CE-79E7-4BCD-98FD-660273616729Q50299137-93E49173-0B74-474F-AB26-DA1C56176A7CQ50299138-717778C4-7E7D-4903-8CC3-725F7B450D89Q50299139-133DD435-21DC-4A51-9106-059CB39DD527Q50299142-24C19439-11F2-4459-837E-8F3019F5ACFCQ50299143-5147968A-EAC6-4423-B735-82E1EA2ABE71Q50299146-6507447C-D503-499D-84D4-458CECDD8336Q50299148-4A027959-6F56-4E5A-86E1-31062463AC9FQ56858522-CC9C160A-6994-4A12-B243-0847A03B644A
P527
Q22007981-48E428A7-29B2-4E1F-A3D4-62C1810A6299Q22010498-322FF1C7-B4FA-4A7F-A5E5-CE54B83D7192Q22011155-B2EC60A5-D9A1-4CBA-9FBE-4B9AD3F1915CQ22253866-A604CE8C-1365-4693-904E-3251D714F453Q22254305-6042F7AE-F2E0-42A5-94B3-126527528EA3Q22254699-7C16DEC6-08E4-4F64-869E-F1F8283DEA1DQ24273420-9E776AEA-8612-4F26-847B-73A9E61783D9Q24292946-468BF68C-8C73-4AD3-9298-8AD1AE2F1F54Q24294392-3D7CFFB7-5215-45B1-969C-DCFCD2F83259Q24295164-665202A4-DD28-43B0-B067-DE924682D4F8Q24297332-2D6B2C25-3E80-40CA-A950-AAA412C00743Q24298127-5736BCB6-E964-4228-A480-7867D3426A90Q24298305-DB331EFF-596F-49E9-9E6E-9DAD82F396ACQ24300565-AFD903BD-66FA-47CB-A598-941F139F485CQ24303650-B9A95A02-5EEF-44A4-88C4-001FDDBC79D8Q24310394-AC17796B-A107-4B3B-B828-F6F95553EEC8Q24317714-54102CD7-9C58-49EF-8984-3FC60D652B81Q24320313-A374ECBA-67FA-4F49-A66A-4473AD8FF980Q24321834-123A3238-B0AB-4B0F-8127-897692F9D0C6Q24322051-5DD7E7B2-F168-4DE5-AC0A-B7E5654D1FA2Q24322705-ECA2ECA1-F28B-4204-92B2-6F483FA66422Q24336385-9E1D59BE-2AFB-4F79-8C77-9082A0308EACQ24337323-0E29C28E-12E9-4855-91BD-0DE3AF67F9FBQ24655473-79E6EEAA-653C-471F-8C59-F29ECF85B35DQ28114928-4E43B2BD-1BF9-4515-A1DF-AFE0A7E8C50BQ28117749-4C477419-B428-4E78-B22F-CF7332E018E0Q28941768-AFC767D9-E414-4458-96B7-88BA452618BEQ28975741-76274FFF-189A-4E76-84BC-602A89660882Q28975767-B85615EF-CE7B-430A-ADEB-E7521B420A0AQ35711530-E19FEE18-906B-478E-A52B-8D207A4C1FACQ37483116-78D50B98-5B12-4616-BEE6-98596D74DF49
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Phosphatase and tensin homolog
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
PTEN
@de
PTEN
@es
PTEN
@fi
PTEN
@fr
PTEN
@gl
PTEN
@id
PTEN
@ja
PTEN
@pl
PTEN
@ru
PTEN
@uk
type
label
PTEN
@de
PTEN
@es
PTEN
@fi
PTEN
@fr
PTEN
@gl
PTEN
@id
PTEN
@ja
PTEN
@pl
PTEN
@ru
PTEN
@uk
altLabel
Gène PTEN
@fr
MMAC1 phosphatase and tensin homolog deleted on chromosome 10
@en
PTEN
@ar
PTEN
@en
PTENepsilon
@en
Phosphatase PTEN
@de
mitochondrial PTENalpha
@en
mitochondrial phosphatase and tensin protein alpha
@en
mutated in multiple advanced cancers 1
@en
phosphatase and tensin-like protein
@en
prefLabel
PTEN
@de
PTEN
@es
PTEN
@fi
PTEN
@fr
PTEN
@gl
PTEN
@id
PTEN
@ja
PTEN
@pl
PTEN
@ru
PTEN
@uk
P527
P637
P638
P680
P681
P682
P705
P352
P6366
P646
P2888
P31
P352
P361
P527
P6366
2777609662
P637
NP_001291646
NP_001291647
P638
P646
P680
P681
P682
P702
P703
P705
ENSP00000361021
ENSP00000483066
ENSP00000494918
ENSP00000495622