The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7
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Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchorsThe R7 RGS protein family: multi-subunit regulators of neuronal G protein signalingGenetic ablation of Pannexin1 protects retinal neurons from ischemic injuryG protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalizationThe evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21.RSBP-1 is a membrane-targeting subunit required by the Galpha(q)-specific but not the Galpha(o)-specific R7 regulator of G protein signaling in Caenorhabditis elegans.RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling.RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivoDifferential effects of the Gβ5-RGS7 complex on muscarinic M3 receptor-induced Ca2+ influx and release.cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membraneThinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.Helix 8 and the i3 loop of the muscarinic M3 receptor are crucial sites for its regulation by the Gβ5-RGS7 complex.Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice.Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptorsβ-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation.Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the BrainFine Mapping of the Body Fat QTL on Human Chromosome 1q43.Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells.GIRK channel modulation by assembly with allosterically regulated RGS proteinsRegulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein.Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity.Overexpression of regulator of G protein signaling 11 promotes cell migration and associates with advanced stages and aggressiveness of lung adenocarcinoma.Regulator of G-protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion.Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13.Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7.The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1-Pyrazol-4-yl)-2-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats NO/cGMO Pathway
P2860
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P2860
The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
The Gbeta5-RGS7 complex select ...... tor and the DEP domain of RGS7
@en
type
label
The Gbeta5-RGS7 complex select ...... tor and the DEP domain of RGS7
@en
prefLabel
The Gbeta5-RGS7 complex select ...... tor and the DEP domain of RGS7
@en
P2860
P356
P1433
P1476
The Gbeta5-RGS7 complex select ...... tor and the DEP domain of RGS7
@en
P2093
Simone L Sandiford
Vladlen Z Slepak
P2860
P304
P356
10.1021/BI801989C
P407
P577
2009-03-01T00:00:00Z