AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. - Test2 - elhamkhani - TriplyDB

AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.

AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.

http://www.wikidata.org/entity/Q41849042

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Transcriptional regulation by AIRE: molecular mechanisms of central tolerance Ovarian autoimmune disease: clinical concepts and animal models Promiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More?Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells.Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5.Expression of thyrotropin receptor, thyroglobulin, sodium-iodide symporter, and thyroperoxidase by fibrocytes depends on AIRE.Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells Transcriptional regulation and its misregulation in disease.In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation.Control of central and peripheral tolerance by Aire.APECED: A Paradigm of Complex Interactions between Genetic Background and Susceptibility Factors Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding.Clues to immune tolerance: the monogenic autoimmune syndromes Both polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells.Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice.Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes.Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells Aire controls gene expression in the thymic epithelium with ordered stochasticity Aire promotes the self-renewal of embryonic stem cells through Lin28.Central tolerance to self revealed by the autoimmune regulator.Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance Transcriptional impact of Aire varies with cell type.Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation Human APECED; a Sick Thymus Syndrome?Cyclin T2 is essential for mouse embryogenesis.PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus.P-TEFb- the final frontier.Monogenic autoimmune diseases: insights into self-tolerance.MYC and transcription elongation.Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells.An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.AIRE in the thymus and beyond.The role of Aire in clonal selection.Lymph node stroma broaden the peripheral tolerance paradigm.Models of aire-dependent gene regulation for thymic negative selection.Genetic basis of altered central tolerance and autoimmune diseases: a lesson from AIRE mutations.

P2860

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P2860

AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.

http://www.wikidata.org/entity/Q41849042

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

AIRE recruits P-TEFb for trans ...... llary thymic epithelial cells.

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type

label

AIRE recruits P-TEFb for trans ...... llary thymic epithelial cells.

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AIRE recruits P-TEFb for trans ...... llary thymic epithelial cells.

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Molecular and Cellular Biology

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AIRE recruits P-TEFb for trans ...... llary thymic epithelial cells.

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P2093

B Matija Peterlin

http://www.w3.org/2001/XMLSchema#string

Irena Oven

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Jiri Kohoutek

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Mojca Narat

http://www.w3.org/2001/XMLSchema#string

Nadezda Brdicková

http://www.w3.org/2001/XMLSchema#string

Tomaz Vaupotic

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P2860

The autoimmune regulator (AIRE) is a DNA-binding protein

Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells

Chromosomal clustering of genes controlled by the aire transcription factor.

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

Three functional classes of transcriptional activation domain

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

Positional cloning of the APECED gene

Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation

The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

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8815-8823

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10.1128/MCB.01085-07

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24

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27

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2007-10-15T00:00:00Z

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17938200

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2169392

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