AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.
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Transcriptional regulation by AIRE: molecular mechanisms of central toleranceOvarian autoimmune disease: clinical concepts and animal modelsPromiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More?Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells.Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5.Expression of thyrotropin receptor, thyroglobulin, sodium-iodide symporter, and thyroperoxidase by fibrocytes depends on AIRE.Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cellsTranscriptional regulation and its misregulation in disease.In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation.Control of central and peripheral tolerance by Aire.APECED: A Paradigm of Complex Interactions between Genetic Background and Susceptibility FactorsHuman T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding.Clues to immune tolerance: the monogenic autoimmune syndromesBoth polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells.Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice.Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cellsUnmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes.Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cellsAire controls gene expression in the thymic epithelium with ordered stochasticityAire promotes the self-renewal of embryonic stem cells through Lin28.Central tolerance to self revealed by the autoimmune regulator.Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.Aire's plant homeodomain(PHD)-2 is critical for induction of immunological toleranceTranscriptional impact of Aire varies with cell type.Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiationHuman APECED; a Sick Thymus Syndrome?Cyclin T2 is essential for mouse embryogenesis.PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus.P-TEFb- the final frontier.Monogenic autoimmune diseases: insights into self-tolerance.MYC and transcription elongation.Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells.An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.AIRE in the thymus and beyond.The role of Aire in clonal selection.Lymph node stroma broaden the peripheral tolerance paradigm.Models of aire-dependent gene regulation for thymic negative selection.Genetic basis of altered central tolerance and autoimmune diseases: a lesson from AIRE mutations.
P2860
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P2860
AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
AIRE recruits P-TEFb for trans ...... llary thymic epithelial cells.
@en
type
label
AIRE recruits P-TEFb for trans ...... llary thymic epithelial cells.
@en
prefLabel
AIRE recruits P-TEFb for trans ...... llary thymic epithelial cells.
@en
P2093
P2860
P356
P1476
AIRE recruits P-TEFb for trans ...... llary thymic epithelial cells.
@en
P2093
B Matija Peterlin
Irena Oven
Jiri Kohoutek
Mojca Narat
Nadezda Brdicková
Tomaz Vaupotic
P2860
P304
P356
10.1128/MCB.01085-07
P407
P577
2007-10-15T00:00:00Z