Competing docking interactions can bring about bistability in the MAPK cascade.
about
Small RNAs establish delays and temporal thresholds in gene expressionSelectivity of docking sites in MAPK kinasesNovel Reporter for Faithful Monitoring of ERK2 Dynamics in Living Cells and Model Organisms.A hidden feedback in signaling cascades is revealedIntegrative modelling of the influence of MAPK network on cancer cell fate decisionEnhancement of tunability of MAPK cascade due to coexistence of processive and distributive phosphorylation mechanisms.A combination of multisite phosphorylation and substrate sequestration produces switchlike responses.Signaling properties of a covalent modification cycle are altered by a downstream target.Protein scaffolds can enhance the bistability of multisite phosphorylation systems.Multi-target regulation by small RNAs synchronizes gene expression thresholds and may enhance ultrasensitive behavior.MAP kinase modules: the excursion model and the steps that count.Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.Determinants of cell-to-cell variability in protein kinase signaling.Modelling cellular signalling systems.Substrate-dependent control of ERK phosphorylation can lead to oscillationsERK1 is important for Th2 differentiation and development of experimental asthma.Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to the Emergence of Oscillatory Behaviour and to Ultrasensitivity.Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines.How cells process information: quantification of spatiotemporal signaling dynamics.A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts.MAPK substrate competition integrates patterning signals in the Drosophila embryoEmploying the metabolic "branch point effect" to generate an all-or-none, digital-like response in enzymatic outputs and enzyme-based sensors.Modeling the light- and redox-dependent interaction of PpsR/AppA in Rhodobacter sphaeroides.The effects of intrinsic noise on the behaviour of bistable cell regulatory systems under quasi-steady state conditions.From invasion to latency: intracellular noise and cell motility as key controls of the competition between resource-limited cellular populations.Bistable MAP kinase activity: a plausible mechanism contributing to maintenance of late long-term potentiation.When More Is Less: Dual Phosphorylation Protects Signaling Off State against OverexpressionEmergent memory in cell signaling: Persistent adaptive dynamics in cascades can arise from the diversity of relaxation time-scalesComputational modelling unravels the precise clockwork of cyanobacteria
P2860
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P2860
Competing docking interactions can bring about bistability in the MAPK cascade.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Competing docking interactions can bring about bistability in the MAPK cascade.
@en
type
label
Competing docking interactions can bring about bistability in the MAPK cascade.
@en
prefLabel
Competing docking interactions can bring about bistability in the MAPK cascade.
@en
P2860
P1433
P1476
Competing docking interactions can bring about bistability in the MAPK cascade.
@en
P2093
Birgit Schoeberl
Hanspeter Herzel
P2860
P304
P356
10.1529/BIOPHYSJ.107.109132
P407
P577
2007-05-25T00:00:00Z