The antimalarial activity of Ru-chloroquine complexes against resistant Plasmodium falciparum is related to lipophilicity, basicity, and heme aggregation inhibition ability near water/n-octanol interfaces.

The antimalarial activity of Ru-chloroquine complexes against resistant Plasmodium falciparum is related to lipophilicity, basicity, and heme aggregation inhibition ability near water/n-octanol interfaces.

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http://www.wikidata.org/entity/Q41938737
The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of actionArene-Ru(II)-chloroquine complexes interact with DNA, induce apoptosis on human lymphoid cell lines and display low toxicity to normal mammalian cells.Ruthenium(II) arene complexes with chelating chloroquine analogue ligands: synthesis, characterization and in vitro antimalarial activity.Metal-chloroquine derivatives as possible anti-malarial drugs: evaluation of anti-malarial activity and mode of action.Synthesis, characterization and biological activity of trans-platinum(II) complexes with chloroquine.Searching for new chemotherapies for tropical diseases: ruthenium-clotrimazole complexes display high in vitro activity against Leishmania major and Trypanosoma cruzi and low toxicity toward normal mammalian cells.Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites.An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptakeChloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents.Interactions of arene-Ru(II)-chloroquine complexes of known antimalarial and antitumor activity with human serum albumin (HSA) and transferrinThe mechanism of antimalarial action of [Au(CQ)(PPh(3))]PF(6): structural effects and increased drug lipophilicity enhance heme aggregation inhibition at lipid/water interfaces.Synthesis, structures and anti-malaria activity of some gold(I) phosphine complexes containing seleno- and thiosemicarbazonato ligands.DMSO-mediated ligand dissociation: renaissance for biological activity of N-heterocyclic-[Ru(η6-arene)Cl2] drug candidates.Lipophilicity assessment of ruthenium(II)-arene complexes by the means of reversed-phase thin-layer chromatography and DFT calculations.
P2860

The antimalarial activity of Ru-chloroquine complexes against resistant Plasmodium falciparum is related to lipophilicity, basicity, and heme aggregation inhibition ability near water/n-octanol interfaces.

Item
http://www.wikidata.org/entity/Q41938737
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
The antimalarial activity of R ...... ar water/n-octanol interfaces.
@en
type
label
The antimalarial activity of R ...... ar water/n-octanol interfaces.
@en
prefLabel
The antimalarial activity of R ...... ar water/n-octanol interfaces.
@en
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
The antimalarial activity of R ...... ar water/n-octanol interfaces.
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P577
P5875
P698
P921
P932