Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia. - Test2 - elhamkhani - TriplyDB

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

http://www.wikidata.org/entity/Q41997706

about

Treatment of Complex Regional Pain Syndrome (CRPS) using low dose naltrexone (LDN)Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation Emerging preclinical pharmacological targets for Parkinson's disease Review: Multiple system atrophy: emerging targets for interventional therapies Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins Immunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein Aggregation Neuroinflammation in Parkinson's disease and its potential as therapeutic target Glia and alpha-synuclein in neurodegeneration: A complex interaction The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?M1 and M2 immune activation in Parkinson's Disease: Foe and ally?Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons Seeking a mechanism for the toxicity of oligomeric α-synuclein Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.Phagocytosis of microglia in the central nervous system diseases Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease.New insights on NOX enzymes in the central nervous system.Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.Towards translational therapies for multiple system atrophy Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy Spinal cord transection-induced allodynia in rats--behavioral, physiopathological and pharmacological characterization Microglial activation mediates host neuronal survival induced by neural stem cells.Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.The role of Galectin-3 in α-synuclein-induced microglial activation.Exploring Braak's Hypothesis of Parkinson's Disease.Sequence-dependent internalization of aggregating peptides Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses.Chronic intermittent hypoxia exerts CNS region-specific effects on rat microglial inflammatory and TLR4 gene expression.Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease.Immune aging, dysmetabolism, and inflammation in neurological diseases.Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes.The Interplay between Alpha-Synuclein Clearance and Spreading Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson's disease

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P2860

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

http://www.wikidata.org/entity/Q41997706

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Toll-like receptor 4 is requir ...... on of microglia and astroglia.

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Toll-like receptor 4 is requir ...... ion of microglia and astroglia

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Kathrin Schanda

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Lisa Fellner

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Werner Poewe

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P2860

Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy

A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Alpha-synuclein expression modulates microglial activation phenotype

Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.

Nitrated alpha-synuclein and microglial neuroregulatory activities.

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

The role of microglia and macrophages in the pathophysiology of the CNS.

Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies.

Critical role of truncated α-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease.

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349-360

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10.1002/GLIA.22437

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3

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61

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Lars Klimaschewski

Regina Irschick

Nadia Stefanova

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2012-10-25T00:00:00Z

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232738418

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23108585

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Toll-like receptor

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3568908

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