Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.

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http://www.wikidata.org/entity/Q42005467

Q42005467

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Targeting Reactive Carbonyl Species with Natural Sequestering Agents The 2013 SFRBM discovery award: selected discoveries from the butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment Emerging drug targets for Aβ and tau in Alzheimer's disease: a systematic review An overview on the correlation of neurological disorders with cardiovascular disease.Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.Administration of NaHS Attenuates Footshock-Induced Pathologies and Emotional and Cognitive Dysfunction in Triple Transgenic Alzheimer's Mice.Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease DNA Demethylation Upregulated Nrf2 Expression in Alzheimer's Disease Cellular Model GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion.Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.Dietary Intake of Nutrients and Lifestyle Affect the Risk of Mild Cognitive Impairment in the Chinese Elderly Population: A Cross-Sectional Study Protein phosphorylation in neurodegeneration: friend or foe?Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases.Glycogen synthase kinase-3 as a therapeutic target for cognitive dysfunction in neuropsychiatric disorders.The biomarker and therapeutic potential of miRNA in Alzheimer's disease.Activation of the 5'-AMP-Activated Protein Kinase in the Cerebral Cortex of Young Senescence-Accelerated P8 Mice and Association with GSK3β- and PP2A-Dependent Inhibition of p-tau₃₉₆ Expression.The effect of Bacopa monnieri on gene expression levels in SH-SY5Y human neuroblastoma cells.Impact of reactive oxygen species generation on Helicobacter pylori-related extragastric diseases: a hypothesis.Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease.The meta-analytical paradigm in an in silico hybrid: Pathways and networks perturbed during exposure to varying degrees of hypobaric hypoxia.Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Asynchronous therapy targeting Nogo-A enhances neurobehavioral recovery by reducing neuronal loss and promoting neurite outgrowth after cerebral ischemia in mice.Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD.Central Nervous System Delivery of Intranasal Insulin: Mechanisms of Uptake and Effects on Cognition.Antisense against Amyloid-β Protein Precursor Reverses Memory Deficits and Alters Gene Expression in Neurotropic and Insulin-Signaling Pathways in SAMP8 Mice.Oligonucleotide therapies for disorders of the nervous system.Peripheral Administration of GSK-3β Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer's Disease.Nucleic Acid-Based Theranostics for Tackling Alzheimer's Disease.Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling.Downregulated Nuclear Factor E2-Related Factor 2 (Nrf2) Aggravates Cognitive Impairments via Neuroinflammation and Synaptic Plasticity in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Mouse: A Model of Accelerated Senescence.Heme Oxygenase-1 Activity as a Correlate to Exercise-Mediated Amelioration of Cognitive Decline and Neuropathological Alterations in an Aging Rat Model of Dementia.Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models

P2860

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P2860

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.

Item

http://www.wikidata.org/entity/Q42005467

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Antisense oligonucleotide agai ...... cations for Alzheimer disease.

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Antisense oligonucleotide agai ...... cations for Alzheimer disease.

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type

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Antisense oligonucleotide agai ...... cations for Alzheimer disease.

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Antisense oligonucleotide agai ...... cations for Alzheimer disease.

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Antisense oligonucleotide agai ...... cations for Alzheimer disease.

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Antisense oligonucleotide agai ...... cations for Alzheimer disease.

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P1476

Antisense oligonucleotide agai ...... cations for Alzheimer disease.

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P2093

Jessica L Ripley

http://www.w3.org/2001/XMLSchema#string

John E Morley

http://www.w3.org/2001/XMLSchema#string

M Paul Murphy

http://www.w3.org/2001/XMLSchema#string

Michael L Niehoff

http://www.w3.org/2001/XMLSchema#string

Rukhsana Sultana

http://www.w3.org/2001/XMLSchema#string

Susan A Farr

http://www.w3.org/2001/XMLSchema#string

Thomas L Platt

http://www.w3.org/2001/XMLSchema#string

Vijaya Kumar

http://www.w3.org/2001/XMLSchema#string

Zhaoshu Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics

Measurement of protein using bicinchoninic acid

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Molecular cloning and expression of glycogen synthase kinase-3/factor A

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

P304

387-395

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scholarly article

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10.1016/J.FREERADBIOMED.2013.11.014

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P478

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D Allan Butterfield

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2013-12-16T00:00:00Z

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24355211

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Alzheimer's disease

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3945161

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Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.

about

P2860

P2860

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.

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