A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties.
about
The nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamilyContrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptorsVirtual screening on an α-helix to β-strand switchable region of the FGFR2 extracellular domain revealed positive and negative modulators.Atomistic insights into human Cys-loop receptors by solution NMR.Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptorsActivation of α7 nicotinic receptors by orthosteric and allosteric agonists: influence on single-channel kinetics and conductanceCritical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance to spinosad in Frankliniella occidentalis.Cholinergic Targets in Lung CancerMicrowave-assisted Expeditious and Efficient Synthesis of Cyclopentene Ring-fused Tetrahydroquinoline Derivatives Using Three-component Povarov Reaction.Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotiUnderstanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery.1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties.The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.Nicotinic acetylcholine receptors at the single-channel level.Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.Beta Amyloid Differently Modulate Nicotinic and Muscarinic Receptor Subtypes which Stimulate in vitro and in vivo the Release of Glycine in the Rat Hippocampus.Auto-inhibition at a ligand-gated ion channel: a cross-talk between orthosteric and allosteric sites.The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs.Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model.Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor
P2860
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P2860
A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
A series of α7 nicotinic acety ...... se pharmacological properties.
@en
A series of α7 nicotinic acety ...... se pharmacological properties.
@nl
type
label
A series of α7 nicotinic acety ...... se pharmacological properties.
@en
A series of α7 nicotinic acety ...... se pharmacological properties.
@nl
prefLabel
A series of α7 nicotinic acety ...... se pharmacological properties.
@en
A series of α7 nicotinic acety ...... se pharmacological properties.
@nl
P2093
P2860
P356
P1476
A series of α7 nicotinic acety ...... se pharmacological properties.
@en
P2093
Emanuele Sher
JasKiran K Gill
Neil S Millar
Persis Dhankher
P2860
P304
P356
10.1124/MOL.111.076026
P577
2012-02-10T00:00:00Z