ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
about
DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsRole of Deubiquitinating Enzymes in DNA RepairDeubiquitinating enzymes in cellular signaling and disease regulationDeubiquitinating enzymes as oncotargetsThe catalytic role of the M2 metal ion in PP2CαComplementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.The Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiaeUVSSA and USP7, a new couple in transcription-coupled DNA repairPhosphatidylinositol-3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphataseUSP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy.TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability.The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilizationATM prevents DSB formation by coordinating SSB repair and cell cycle progression.Annexin-1 regulated by HAUSP is essential for UV-induced damage response.A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription FactorsThe de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors.HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage responsePPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.The Regulation of Multiple p53 Stress Responses is Mediated through MDM2Deubiquitinases as a signaling target of oxidative stress.Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicitySerine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destructionStabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis.Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1)CtIP is required for DNA damage-dependent induction of P21.The regulation of MDM2 oncogene and its impact on human cancers.Regulation of human MutYH DNA glycosylase by the E3 ubiquitin ligase mule.Deubiquitylating enzymes and DNA damage response pathways.Targeting CK2-driven non-oncogene addiction in B-cell tumors.FOXM1 binds directly to non-consensus sequences in the human genome.The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrityHAUSP compartmentalization in chronic myeloid leukemia.Nuclear phosphatase PPM1G in cellular survival and neural development.USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair.Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones.Regulation of p27Kip1 phosphorylation and G1 cell cycle progression by protein phosphatase PPM1G.
P2860
Q26741797-3C7A973D-1DB2-4C60-8DA5-7DA19EC3F868Q26773800-F0D4A993-632A-4857-8FEE-58C3D31813A0Q26801232-E992BEFF-9FD8-471F-877E-3D5AA37A4E6CQ27026189-34F1BE27-C7A8-4474-85B0-84717DFDCDD1Q27698056-E732A258-1D86-4EE6-92B4-07CEFA98E29CQ27853152-1378F4F0-DA3B-418A-8020-EF35DEAC532CQ27932371-3B83A934-2882-4331-B8F5-842B415D51B9Q28292625-1FD3B018-4B68-4C18-A43E-72E1D4888BECQ28821984-7DE541E8-A112-4BC9-9957-333E6381797BQ33701405-3924284D-DBE0-4F4A-82F4-12B9A8217484Q33721242-771C9BF1-453F-404C-9EA6-DD6C499092ECQ34480316-2D3F13B2-B463-41A0-8D45-25E60D4E9CADQ35156678-4F7764A6-6BEF-414D-A4C6-41448D082604Q35279815-45FE9528-9539-46B7-A704-FEE8CC040440Q35563921-820698BB-EBB6-430E-9339-A64082EAB72BQ35640249-0601DA7F-3A17-4857-A0F5-FDBD9AC91867Q35909722-86C2F608-9613-4B7F-BE25-658F6B7082B1Q35913537-D8DD911D-F6BB-42F3-8B20-EA03A9982E7AQ36174095-6104DB88-16D0-4731-ADA2-A08C58768E32Q36387610-A1744902-1FA5-4CE9-8B0C-0D7F8D2A1C61Q36501472-10067993-0247-427B-8E7A-7E812F55CE63Q36615629-8D3AE512-E8B2-4697-92EE-0A79163318ECQ36743136-16B910BE-F3AD-4C56-AEF1-20F3707339D7Q36862753-9BFEBD90-2A86-4FB3-A2FE-9FC88A31E7CAQ36951802-A08B7112-BF73-4AD6-A6A5-D2BA8DEC896DQ37095424-7C00F246-46C6-4F4E-B60A-6C02822802DDQ37587039-B47FEF78-66C1-481C-B4F2-F21C43B57E4DQ37599707-66E04E89-B939-449E-AABB-834402E632CFQ37622650-3BFBCDB2-880D-4BE1-BADC-159ED73B6360Q38109871-6746B468-93E8-49F3-AB56-42104F413374Q38797342-DFA45D9B-C87D-4189-ABFE-99891B206CB8Q38861035-D31CF413-C745-48F0-9D15-FC4BAF76608AQ38888300-FA297652-4A69-4D83-9600-6C39AECA59C5Q38956821-96905B7A-825D-4AA5-9776-A2BCC7B032C6Q38959150-50519D39-219E-485F-B37A-BBD311639AA6Q38969685-CE6C637D-9BBB-4BFC-A109-7F8337CBA483Q39145471-B7F6FD42-02A9-4E62-9320-3C2A3CE43C70Q39218699-BBFB4784-D324-4D00-8895-D95779B533E8Q41056246-FCAB2BCB-E43B-458F-9D02-64DE3AFD5513Q41632273-81F58543-BC25-419E-9967-26E4CC282809
P2860
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
@en
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
@nl
type
label
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
@en
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
@nl
prefLabel
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
@en
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
@nl
P2093
P2860
P50
P1433
P1476
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
@en
P2093
Grigory L Dianov
Irina I Dianova
Svetlana V Khoronenkova
P2860
P304
P356
10.1016/J.MOLCEL.2012.01.021
P577
2012-02-21T00:00:00Z