%D9%85%D8%B3%D8%AA%D9%82%D8%A8%D9%84_%D8%B9%D8%A7%D9%85%D9%84_%D9%86%D9%85%D9%88_%D8%A7%D9%84%D8%A8%D8%B4%D8%B1%D8%A9EGFREGF-RezeptorEpidermal_growth_factor_receptorReceptor_del_factor_de_crecimiento_epid%C3%A9rmicoEGFREpidermaalisen_kasvutekij%C3%A4n_reseptoriR%C3%A9cepteur_de_l%27EGFRecettore_del_fattore_di_crescita_dell%27epidermide%E4%B8%8A%E7%9A%AE%E6%88%90%E9%95%B7%E5%9B%A0%E5%AD%90%E5%8F%97%E5%AE%B9%E4%BD%93Receptor_EGFReceptor_do_fator_de_crescimento_epid%C3%A9rmico%D0%A0%D0%B5%D1%86%D0%B5%D0%BF%D1%82%D0%BE%D1%80_%D1%8D%D0%BF%D0%B8%D0%B4%D0%B5%D1%80%D0%BC%D0%B0%D0%BB%D1%8C%D0%BD%D0%BE%D0%B3%D0%BE_%D1%84%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D0%B0_%D1%80%D0%BE%D1%81%D1%82%D0%B0Receptor_epidermalnog_faktora_rastaReceptor_epidermalnog_faktora_rasta%E0%AE%AA%E0%AF%81%E0%AE%B1%E0%AE%A4%E0%AF%8D%E0%AE%A4%E0%AF%8B%E0%AE%B2%E0%AF%8D_%E0%AE%B5%E0%AE%B3%E0%AE%B0%E0%AF%8D%E0%AE%95%E0%AE%BE%E0%AE%B0%E0%AE%A3%E0%AE%BF_%E0%AE%8F%E0%AE%B1%E0%AF%8D%E0%AE%AA%E0%AE%BFEpidermal_b%C3%BCy%C3%BCme_fakt%C3%B6r%C3%BC_resept%C3%B6r%C3%BC%D0%A0%D0%B5%D1%86%D0%B5%D0%BF%D1%82%D0%BE%D1%80_%D0%B5%D0%BF%D1%96%D0%B4%D0%B5%D1%80%D0%BC%D0%B0%D0%BB%D1%8C%D0%BD%D0%BE%D0%B3%D0%BE_%D1%84%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D0%B0_%D1%80%D0%BE%D1%81%D1%82%D1%83%D8%A8%D8%B4%D8%B1%D9%88%DB%8C_%D9%86%D9%85%D9%88%D8%A6%DB%8C_%D8%B9%D8%A7%D9%85%D9%84_%D8%AD%D8%A7%D8%B5%D9%84%DB%81Q424401%E8%A1%A8%E7%9A%AE%E7%94%9F%E9%95%BF%E5%9B%A0%E5%AD%90%E5%8F%97%E4%BD%93
about
sameAs
L-leucine 858 replaced with L-arginineglycine 719 replaced with L-serineEGFR ser-750 ser-748 ser-746 ser-749 ser-747 phosphorylatedL-proline 753 replaced with L-serineL-threonine 790 replaced with L-methionineEGFR ser-1068 ser-1148 ser-1173 ser-1086 ser-992 ser-1045 ser-750 ser-748 ser-746 ser-749 ser-747 phosphorylatedL-proline 753 replaced with L-serine ser-1045 ser-1068 ser-1086 ser-1148 ser-1173 ser-992 phosphorylatedL-arginine 297 replaced with glycineL-arginine 297 replaced with glycine ser-1068 ser-1086 ser-1173 ser-992 ser-1148 phosphorylatedEGFR ser-992 ser-1045 ser-1068 ser-1086 ser-1148 ser-1173 phosphorylatedEGFR ser-1068 ser-1148 ser-1173 ser-1086 phosphorylatedEGFR ser-992 ser-1045 ser-1068 ser-1086 ser-1173 phosphorylatedL-threonine 790 replaced with L-methionine [plasma membrane]L-leucine 858 replaced with L-arginine [plasma membrane]glycine 719 replaced with L-serine [plasma membrane]EGFR ser-992 ser-1045 ser-1068 ser-1086 ser-1148 ser-1173 phosphorylated [clathrin-coated vesicle membrane]p-6Y-EGFR E746_A750del;T790M [plasma membrane]p-6Y-EGFR L858R;T790M [plasma membrane]
P279
L1-EGFR trans-heterodimerLigand-responsive EGFR mutants sensitive to non-covalent TKIsLigand-responsive EGFR mutants resistant to non-covalent TKIsLigand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIsLigand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIsEGFR:CetuximabEGF:EGFRHBEGF:EGFRL1-EGFR trans-heterodimerizationInactivation of over-expressed wild type EGFR by Cetuximab recombinant antibodyEGFR gene expression is stimulated by TFAP2CEGFR binds EGF ligandMature HBEGF binds to EGFR; triggering dimerisation and autophosphorylation of the receptor
P527
P688
Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicityRegulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptorPlasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptorSegregation of receptor and ligand regulates activation of epithelial growth factor receptorComparative analysis of fluorescence resonance energy transfer (FRET) and proximity ligation assay (PLA)ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNAIn situ analysis of mutant EGFRs prevalent in glioblastoma multiforme reveals aberrant dimerization, activation, and differential response to anti-EGFR targeted therapyTransforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-{beta} functionSorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domainEpidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancerA proximity ligation assay using transiently transfected, epitope-tagged proteins: application for in situ detection of dimerized receptor tyrosine kinasesUbiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitmentActivation of epidermal growth factor receptor signals induction of nitric oxide synthase-2 in human optic nerve head astrocytes in glaucomatous optic neuropathyMechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segmentThe epidermal growth factor receptors and their family of ligands: their putative role in atherogenesisUVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytesConformational coupling across the plasma membrane in activation of the EGF receptorExpression of a truncated epidermal growth factor receptor-like protein (TEGFR) in ovarian cancerWT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosisActivation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosisThe evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activityMice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heartThree distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferationTyrosine phosphorylation controls PCNA function through protein stabilityEpidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surfaceThe E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptorEpidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivoFlow cytometric in situ proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor familyParallel visualization of multiple protein complexes in individual cells in tumor tissueOncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerizationNuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblastsEGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healingEpidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cellsActivated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradationVps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradationEGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastomaSNX12 role in endosome membrane transportPI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancerFunctional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
P921
Q16868421-7C2E44E8-867A-42E5-BD7A-AB2ADE7DC784Q17130597-3F2F2A5D-72A7-447F-BF4B-1E16993A1737Q21166972-A221A730-B625-48F8-912F-1D0C34CC8CDBQ21172704-41154E35-8A8C-4CB9-9CA6-2EB7F042820BQ21506464-793CB94F-34AE-4BC2-8EA9-845862814FC4Q417824-C9C3CB4D-CF47-4339-A1A3-6EEE1F8ACE11Q418369-82C894E7-D004-4D18-BDEF-B3DAF4902C59Q420323-0B945B87-F3E7-43D6-954C-A91ECDED8103Q4653190-B6AED062-F882-4445-9467-FCB2B8C46652Q4688818-347E0A69-1E0A-40DC-B76E-DAC6D88A3A8FQ5032274-11147B23-FB1E-4835-96E7-64C679D43D00Q6995920-DC8431CF-3826-412B-8581-D38DC8F3B674Q7914515-1A1FEAFD-826E-46E5-903A-88AD975CF1C7
P129
Q50369594-2A22B204-32C4-41C6-8AE4-10CA6FC9755AQ50369595-C96BA029-CCA8-4462-B45E-53682237F54CQ50369596-B613EEDD-BE06-41D5-9832-78EC3A157B57Q50369597-5F035FD9-566B-4925-B13C-155CE2C07637Q50369598-23AEB725-FBDE-4C86-88BF-78D87934F86AQ50369603-FB190107-185D-45CB-8FDA-89623B0BB3FDQ50369605-B4BA3C31-7F81-4EA4-950C-FC8185DB27D8Q50369609-8D5B6BB0-BA44-4FC2-8C64-31E0C807DE9CQ50369610-6E562054-736C-4962-A61E-695C22D4F641Q50369732-2ABB4FA0-B02B-4A52-8F79-838216FBE361Q50374030-B2C29B26-04A6-4DDC-86FC-76AF35BDA6B9Q50374036-37FC5488-6F95-4358-9C5A-2462C70FA2E5Q50677165-0EDC4234-F6F2-48C0-B502-59693ED39AB3Q50677172-943AF0BF-FA11-4C6F-802C-A3F8410370DFQ50677174-0089B9DC-9F22-435F-8A12-D628B084C0FEQ50682050-64C6668D-4057-4892-8086-7BE0D5C473E1Q50684266-9277BE63-84D1-4B93-8258-DB74A3662938Q50684269-A921A668-7457-47DE-8A4A-EC37BE7FB521
P279
Q50254575-ACB692E6-A222-4AC1-84D0-4ED444A88C8AQ50255450-1503D672-0391-4432-95D6-A44E97A2BC72Q50255451-82E1FFE6-652A-4CCA-8654-AEE7AE4B1E1DQ50255470-54AE27BF-0119-450E-BFE3-E66A0D420E99Q50255472-212AA80D-F969-4679-8536-097217331362Q50255520-203A71CE-E2F9-4B1B-A15C-7CCC20B595D7Q50255522-DF43D86E-AC30-4B86-A97A-F61C55ED3683Q50274316-9C6E40CB-CA55-4211-A60A-C84D99F39DE1Q50287677-D7DA1B91-4E0B-4062-9A4B-B2EECC0BE158Q50288651-543F7C7C-5BDD-4816-861F-B38AB87A9DD3Q50290441-309156FC-08F6-447C-B5AB-9DA8A4461BBDQ50297456-7296D7FB-5456-4ADF-AE55-E2F90CA57C22Q50298516-8421D823-493D-4B52-8F20-D559A926DD94
P527
description
Protein
@de
białko
@pl
mammalian protein found in Homo sapiens
@en
mammalsk protein hos arten Homo sapiens
@nn
protein
@id
protein
@sv
proteinë
@sq
proteïne in Epidermal growth factor receptor
@nl
protèin
@ace
protéine
@fr
name
EGF-Rezeptor
@de
EGFR
@cy
EGFR
@et
EGFR
@vi
Epidermaalisen kasvutekijän reseptori
@fi
Epidermal büyüme faktörü reseptörü
@tr
Epidermal growth factor receptor
@en
Epidermal growth factor receptor
@nl
Receptor do fator de crescimento epidérmico
@pt
Receptor epidermalnog faktora rasta
@sh
type
label
EGF-Rezeptor
@de
EGFR
@cy
EGFR
@et
EGFR
@vi
Epidermaalisen kasvutekijän reseptori
@fi
Epidermal büyüme faktörü reseptörü
@tr
Epidermal growth factor receptor
@en
Epidermal growth factor receptor
@nl
Receptor do fator de crescimento epidérmico
@pt
Receptor epidermalnog faktora rasta
@sh
altLabel
EGF-R
@tr
EGFR
@de
EGFR
@en
EGFR
@es
EGFR
@fi
EGFR
@it
EGFR
@ja
EGFR
@nn
EGFR
@pl
EGFR
@pt
prefLabel
EGF-Rezeptor
@de
EGFR
@cy
EGFR
@et
EGFR
@vi
Epidermaalisen kasvutekijän reseptori
@fi
Epidermal büyüme faktörü reseptörü
@tr
Epidermal growth factor receptor
@en
Epidermal growth factor receptor
@nl
Receptor do fator de crescimento epidérmico
@pt
Receptor epidermalnog faktora rasta
@sh
P129
P361
P527
P637
P638
P680
P681
P682
P705
P352
P486
P6366
P637
P646
P2888
P31
P352
P361
P486
P527
P6366
2777506169
2779438470
P637
NP_001333826
NP_001333827
NP_001333828
NP_001333829
NP_001333870
P638
P646
P680
P681
P682
P702
P703
P705
ENSP00000275493
ENSP00000342376
ENSP00000345973
ENSP00000395243
ENSP00000413354
ENSP00000413843
ENSP00000415559
ENSP00000492462