Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase. - Test2 - elhamkhani - TriplyDB

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.

http://www.wikidata.org/entity/Q42524332

about

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation Regulated association of protein kinase B/Akt with breast tumor kinase Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics Modulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxia Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms.Effects of resveratrol on the insulin signaling pathway of obese mice Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1 Androgen receptor levels are upregulated by Akt in prostate cancer.Identification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics.Targeting the PI3-kinase/Akt/mTOR signaling pathway.Arsenic alters vascular smooth muscle cell focal adhesion complexes leading to activation of FAK-src mediated pathways.3-D structure and dynamics of protein kinase B-new mechanism for the allosteric regulation of an AGC kinase.Akt/PKB: one kinase, many modifications.Palmitate contributes to insulin resistance through downregulation of the Src-mediated phosphorylation of Akt in C2C12 myotubes.Regulation of mTORC1 signaling by Src kinase activity is Akt1-independent in RSV-transformed cells Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549.Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle.Quantitative analysis of Akt phosphorylation and activity in response to EGF and insulin treatment.Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma Phosphorylation site mapping of endogenous proteins: a combined MS and bioinformatics approach.Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis.Tonic B-cell receptor signaling in diffuse large B-cell lymphoma.IGF-I-induced oligodendrocyte progenitor proliferation requires PI3K/Akt, MEK/ERK, and Src-like tyrosine kinases.The Akt pathway in oncology therapy and beyond (Review)

P2860

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P2860

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.

http://www.wikidata.org/entity/Q42524332

description

2002 nî lūn-bûn

@nan

2002年の論文

@ja

2002年学术文章

@wuu

2002年学术文章

@zh-cn

2002年学术文章

@zh-hans

2002年学术文章

@zh-my

2002年学术文章

@zh-sg

2002年學術文章

@yue

2002年學術文章

@zh

2002年學術文章

@zh-hant

name

Direct identification of tyros ...... te for the Akt protein kinase.

@en

Direct identification of tyros ...... te for the Akt protein kinase.

@nl

type

label

Direct identification of tyros ...... te for the Akt protein kinase.

@en

Direct identification of tyros ...... te for the Akt protein kinase.

@nl

prefLabel

Direct identification of tyros ...... te for the Akt protein kinase.

@en

Direct identification of tyros ...... te for the Akt protein kinase.

@nl

P1433

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P921

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P1433

Journal of Biological Chemistry

P1476

Direct identification of tyros ...... te for the Akt protein kinase.

@en

P2093

Brian A Hemmings

http://www.w3.org/2001/XMLSchema#string

Briony E Cristiano

http://www.w3.org/2001/XMLSchema#string

Katherine M Hannan

http://www.w3.org/2001/XMLSchema#string

Nelly Marmy Conus

http://www.w3.org/2001/XMLSchema#string

Richard B Pearson

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

The protooncogene TCL1 is an Akt kinase coactivator

Regulation of Akt/PKB activation by tyrosine phosphorylation

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit

P304

38021-38028

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P31

scholarly article

P356

10.1074/JBC.M203387200

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P407

P433

41

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P478

277

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P577

2002-07-30T00:00:00Z

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P698

12149249

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P921

phosphorylation