Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway
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The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic inventionDisruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarinePhosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradationThe RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damageUBPY: a growth-regulated human ubiquitin isopeptidase.Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛPTEN represses RNA Polymerase I transcription by disrupting the SL1 complexAssociation of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathwayModulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirusCoupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcriptionA novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expressionNitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complexAssembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)The prolyl isomerase Pin1 in breast development and cancerThe HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helixHistone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteinsThe other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axisD-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells.Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure.DNA damage response-mediated degradation of Ho endonuclease via the ubiquitin system involves its nuclear export.Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation.Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeastTargeting CDK4 and CDK6: From Discovery to TherapyDegradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathwayPhosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformationPERK mediates cell-cycle exit during the mammalian unfolded protein responseCharacterization of the mUBC9-binding sites required for E2A protein degradationThe INK4 family of cell cycle inhibitors in cancerThe SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradationAssociation of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific proteaseIn vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agentsRac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerinCyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanismIkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation
P2860
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P2860
Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Inhibition of cyclin D1 phosph ...... e ubiquitin-proteasome pathway
@ast
Inhibition of cyclin D1 phosph ...... e ubiquitin-proteasome pathway
@en
Inhibition of cyclin D1 phosph ...... e ubiquitin-proteasome pathway
@nl
type
label
Inhibition of cyclin D1 phosph ...... e ubiquitin-proteasome pathway
@ast
Inhibition of cyclin D1 phosph ...... e ubiquitin-proteasome pathway
@en
Inhibition of cyclin D1 phosph ...... e ubiquitin-proteasome pathway
@nl
prefLabel
Inhibition of cyclin D1 phosph ...... e ubiquitin-proteasome pathway
@ast
Inhibition of cyclin D1 phosph ...... e ubiquitin-proteasome pathway
@en
Inhibition of cyclin D1 phosph ...... e ubiquitin-proteasome pathway
@nl
P2093
P3181
P356
P1433
P1476
Inhibition of cyclin D1 phosph ...... e ubiquitin-proteasome pathway
@en
P2093
P304
P3181
P356
10.1101/GAD.11.8.957
P407
P577
1997-04-15T00:00:00Z