Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
about
Corresponding functional dynamics across the Hsp90 Chaperone family: insights from a multiscale analysis of MD simulationsConsecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids.Macrocyclic inhibitors of hsp90Molecular dynamics study of naturally existing cavity couplings in proteins.Hitting a Moving Target: How Does an N-Methyl Group Impact Biological Activity?First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.Conformational dynamics of the molecular chaperone Hsp90Hsp70 protein complexes as drug targets.HSP90: chaperone-me-not.Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides.Targeting Hsp90 and its co-chaperones to treat Alzheimer's diseaseNatural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects.Alternative approaches to Hsp90 modulation for the treatment of cancer.Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivatives.Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins.The first report of direct inhibitors that target the C-terminal MEEVD region on heat shock protein 90.Synthesis of sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds.An Hsp90 modulator that exhibits a unique mechanistic profile.Chemically accessible hsp90 inhibitor that does not induce a heat shock responseA heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock responseSpecific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.Insect-specific production of new GameXPeptides in photorhabdus luminescens TTO1, widespread natural products in entomopathogenic bacteria.A highly selective Hsp90 affinity chromatography resin with a cleavable linker.The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis.Effectively delivering a unique hsp90 inhibitor using star polymers.Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90.Dimerization of a heat shock protein 90 inhibitor enhances inhibitory activity.X-Linked Inhibitor of Apoptosis Protein (XIAP) is a Client of Heat Shock Protein 70 (Hsp70) and a Biomarker of its Inhibition.Identification of Hsp90 inhibitors with anti-Plasmodium activity.Reinventing Hsp90 Inhibitors: Blocking C-Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors.Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides.
P2860
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P2860
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
@en
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
@nl
type
label
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
@en
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
@nl
prefLabel
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
@en
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
@nl
P2093
P2860
P356
P1476
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
@en
P2093
Christian N Cunningham
David A Agard
Robert C Vasko
Rodrigo A Rodriguez
Shelli R McAlpine
Veronica C Ardi
P2860
P356
10.1021/ML900003T
P577
2010-01-01T00:00:00Z