about
PHD2: from hypoxia regulation to disease progressionInhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβHIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy.Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injuryMatrilysin (matrix metalloproteinase-7): a new promising drug target in cancer and inflammation?Erythrocytosis: the HIF pathway in control.PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages.PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.Regulation of endothelial migration and proliferation by ephrin-A1.Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells.Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen.Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in miceDetection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor.Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor.Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy.Serine proteases of the fibrinolysis pathway are not involved in lethal hepatitis and fibrinogen breakdown induced by tumor necrosis factor.Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C.HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival.HIF in vascular development and tumour angiogenesis.Erythropoietin directly stimulates osteoclast precursors and induces bone loss.Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia.Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice.HSP70 protects against TNF-induced lethal inflammatory shock.Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock.The use of tissue inhibitors of matrix metalloproteinases to increase the efficacy of a tumor necrosis factor/interferon gamma antitumor therapy.The role of complement activation in tumour necrosis factor-induced lethal hepatitis.Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock.Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis.Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis.Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment.Endothelial Cell-Specific Overexpression of Del-1 Drives Expansion of Haematopoietic Progenitor Cells in the Bone Marrow.Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice.Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C SignalingDEL-1 promotes macrophage efferocytosis and clearance of inflammation
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description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
@hy
name
Ben Wielockx
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Ben Wielockx
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Ben Wielockx
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Ben Wielockx
@nl
Ben Wielockx
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type
label
Ben Wielockx
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Ben Wielockx
@en
Ben Wielockx
@es
Ben Wielockx
@nl
Ben Wielockx
@sl
prefLabel
Ben Wielockx
@ast
Ben Wielockx
@en
Ben Wielockx
@es
Ben Wielockx
@nl
Ben Wielockx
@sl
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0000-0002-4923-2596