HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
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PHD2: from hypoxia regulation to disease progressionThe role of PHD2 mutations in the pathogenesis of erythrocytosis.Subcellular Energetics and Metabolism: A Cross-Species Framework.Current views on cell metabolism in SDHx-related pheochromocytoma and paragangliomaConditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation.A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.Targeting the hypoxia-sensing pathway in clinical hematology.Concise review: genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells.Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism.Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells.Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in miceHematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice.
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P2860
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
description
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name
HIF prolyl hydroxylase 2 (PHD2 ...... uring steady-state and stress.
@en
HIF prolyl hydroxylase 2
@nl
type
label
HIF prolyl hydroxylase 2 (PHD2 ...... uring steady-state and stress.
@en
HIF prolyl hydroxylase 2
@nl
prefLabel
HIF prolyl hydroxylase 2 (PHD2 ...... uring steady-state and stress.
@en
HIF prolyl hydroxylase 2
@nl
P2093
P50
P1433
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HIF prolyl hydroxylase 2 (PHD2 ...... during steady-state and stress
@en
P2093
A Francis Stewart
Agnieszka Gembarska
Antje Muschter
Carsten Willam
Kristin Franke
Rashim Pal Singh
Ronald Naumann
Soulafa Mamlouk
Stefan Bornstein
Tatyana Grinenko
P304
P356
10.1182/BLOOD-2012-12-471185
P407
P577
2013-05-10T00:00:00Z