Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics
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Analysis of Transient and Catalytic Desosamine-binding Pockets in Cytochrome P-450 PikC from Streptomyces venezuelaeSelective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenaseTirandamycin biosynthesis is mediated by co-dependent oxidative enzymesSubstrate Recognition by the Multifunctional Cytochrome P450 MycG in Mycinamicin Hydroxylation and Epoxidation ReactionsA New Structural Form in the SAM/Metal-Dependent O‑Methyltransferase Family: MycE from the Mycinamicin Biosynthetic PathwayCrystal Structure of CYP106A2 in Substrate-Free and Substrate-Bound FormHydrogen peroxide-independent production of α-alkenes by OleTJE P450 fatty acid decarboxylaseSpliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase.Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics.Genetic screening strategy for rapid access to polyether ionophore producers and products in actinomycetesStructural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases.Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis.Reconstitution of the In Vitro Activity of the Cyclosporine-Specific P450 Hydroxylase from Sebekia benihana and Development of a Heterologous Whole-Cell Biotransformation System.Characterization of a Unique Pathway for 4-Cresol Catabolism Initiated by Phosphorylation in Corynebacterium glutamicum.Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants.Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleTJE.New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners.Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.Diversity of P450 enzymes in the biosynthesis of natural productsP450s and UGTs: Key Players in the Structural Diversity of Triterpenoid Saponins.Involvement of SgvP in carbon-sulfur bond formation during Griseoviridin biosynthesis.Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp.Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase.Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis.Structural analysis of SgvP involved in carbon-sulfur bond formation during griseoviridin biosynthesis.Function of cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicinNickel-Catalyzed Regiodivergent Approach to Macrolide MotifsComparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways.Isolation and characterization of 23-O-mycinosyl-20-dihydro-rosamicin: a new rosamicin analogue derived from engineered Micromonospora rosaria.Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns.Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.A metabolic gene cluster in Lotus japonicus discloses novel enzyme functions and products in triterpene biosynthesis.Expansion of chemical space for natural products by uncommon P450 reactions.Investigating the effect of available redox protein ratios for the conversion of a steroid by a myxobacterial CYP260A1.Identification and characterization of gerPI and gerPII involved in epoxidation and hydroxylation of dihydrochalcolactone in Streptomyces species KCTC 0041BP.A new mycinosyl rosamicin derivative produced by an engineered Micromonospora rosaria mutant with a cytochrome P450 gene disruption introducing the D-mycinose biosynthetic gene.Substrate promiscuity of cytochrome P450 RhFCytochromes P450 as useful biocatalysts: addressing the limitations
P2860
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P2860
Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Functional analysis of MycCI a ...... inamicin macrolide antibiotics
@en
Functional analysis of MycCI a ...... inamicin macrolide antibiotics
@nl
type
label
Functional analysis of MycCI a ...... inamicin macrolide antibiotics
@en
Functional analysis of MycCI a ...... inamicin macrolide antibiotics
@nl
prefLabel
Functional analysis of MycCI a ...... inamicin macrolide antibiotics
@en
Functional analysis of MycCI a ...... inamicin macrolide antibiotics
@nl
P2093
P2860
P1476
Functional analysis of MycCI a ...... inamicin macrolide antibiotics
@en
P2093
David H Sherman
Fumio Kato
Kenji Kinoshita
Mani Raj Chaulagain
Shengying Li
Yojiro Anzai
P2860
P304
P356
10.1016/J.CHEMBIOL.2008.07.014
P577
2008-09-01T00:00:00Z