Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase - Test2 - elhamkhani - TriplyDB

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

http://www.wikidata.org/entity/Q27657793

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Structural Evidence for Enhancement of Sequential Vitamin D3 Hydroxylation Activities by Directed Evolution of Cytochrome P450 Vitamin D3 Hydroxylase Substrate Recognition by the Multifunctional Cytochrome P450 MycG in Mycinamicin Hydroxylation and Epoxidation Reactions A New Structural Form in the SAM/Metal-Dependent O‑Methyltransferase Family: MycE from the Mycinamicin Biosynthetic Pathway Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond Oxygenation The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates Hydrogen peroxide-independent production of α-alkenes by OleTJE P450 fatty acid decarboxylase Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1.Cytochrome P450: taming a wild type enzyme Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS.A high-throughput screen for the engineered production of β-lactam antibiotics.Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity Characterization of a Unique Pathway for 4-Cresol Catabolism Initiated by Phosphorylation in Corynebacterium glutamicum.Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates.New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners.Conformational plasticity and structure/function relationships in cytochromes P450.Frontiers and opportunities in chemoenzymatic synthesis.Diversity of P450 enzymes in the biosynthesis of natural products Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds.Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.Engineering of versatile redox partner fusions that support monooxygenase activity of functionally diverse cytochrome P450s.Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations.Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin.Nickel-Catalyzed Regiodivergent Approach to Macrolide Motifs Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways.Anti-Markovnikov alkene oxidation by metal-oxo-mediated enzyme catalysis.Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst.Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system.An artificial self-sufficient cytochrome P450 directly nitrates fluorinated tryptophan analogs with a different regio-selectivity.

P2860

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P2860

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

http://www.wikidata.org/entity/Q27657793

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

@ast

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

@en

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

@nl

type

label

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

@ast

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

@en

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

@nl

prefLabel

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

@ast

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

@en

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

@nl

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PNAS.0907203106

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

@en

P2093

Allison R Knauff

http://www.w3.org/2001/XMLSchema#string

David H Sherman

http://www.w3.org/2001/XMLSchema#string

Larissa M Podust

http://www.w3.org/2001/XMLSchema#string

Mani Raj Chaulagain

http://www.w3.org/2001/XMLSchema#string

Shengying Li

http://www.w3.org/2001/XMLSchema#string

P2860

In the light of directed evolution: pathways of adaptive protein evolution

Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

Analysis of Transient and Catalytic Desosamine-binding Pockets in Cytochrome P-450 PikC from Streptomyces venezuelae

The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae.

Libraries of hybrid proteins from distantly related sequences.

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.

Understanding and exploiting C-H bond activation.

A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis.

Chemo-enzymatic fluorination of unactivated organic compounds.

P304

18463-18468

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scholarly article

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10.1073/PNAS.0907203106

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44

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106

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John Montgomery

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2009-10-15T00:00:00Z

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38015129

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19833867

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2774028

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