about
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptorPerinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase SykMolecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinaseGranulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinasesStress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease.Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavDifferential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domainThe oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signalingThe protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinaseInhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase FgrDAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinaseIdentification of the major sites of autophosphorylation of the murine protein-tyrosine kinase SykThe Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl.Fast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscopeA novel quantitative proteomics strategy to study phosphorylation-dependent peptide-protein interactions.Total internal reflection fluorescence flow cytometryIn-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymersDetection of kinase translocation using microfluidic electroporative flow cytometry.Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers.Getting Syk: spleen tyrosine kinase as a therapeutic target.Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry.Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrapNanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B.In-Depth Analyses of B Cell Signaling Through Tandem Mass Spectrometry of Phosphopeptides Enriched by PolyMAC.Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.Molecular interdiction of Src-family kinase signaling in hematopoietic cells.Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.The microtubule-associated protein tau is phosphorylated by SykSyk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunitModulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells.Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomicsSyk and pTyr'd: Signaling through the B cell antigen receptorRole of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.Anti-sulfonylbenzoate antibodies as a tool for the detection of nucleotide-binding proteins for functional proteomics.Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck.Posttranslational acylation of the transferrin receptor in LSTRA cells with myristate, palmitate and stearate: evidence for distinct acyltransferases.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Robert L. Geahlen
@ast
Robert L. Geahlen
@en
Robert L. Geahlen
@es
Robert L. Geahlen
@nl
Robert L. Geahlen
@sl
type
label
Robert L. Geahlen
@ast
Robert L. Geahlen
@en
Robert L. Geahlen
@es
Robert L. Geahlen
@nl
Robert L. Geahlen
@sl
prefLabel
Robert L. Geahlen
@ast
Robert L. Geahlen
@en
Robert L. Geahlen
@es
Robert L. Geahlen
@nl
Robert L. Geahlen
@sl
P106
P1153
7006104513
P21
P31
P496
0000-0001-8400-2924