Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.
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Effects of repeated treatment with phosphodiesterase-4 inhibitors on cAMP signaling, hippocampal cell proliferation, and behavior in the forced-swim testInactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay.Pharmacological implications of the Ca(2+)/cAMP signaling interaction: from risk for antihypertensive therapy to potential beneficial for neurological and psychiatric disordersPDE4 as a target for cognition enhancementGenes and signaling pathways involved in memory enhancement in mutant miceEfficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis)Structural basis for the design of selective phosphodiesterase 4B inhibitorsPhosphodiesterase 4D: an enzyme to rememberExome sequencing identifies PDE4D mutations as another cause of acrodysostosisPhosphodiesterases as therapeutic targets for Alzheimer's disease.A new model of Pde4d deficiency: genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects.The phosphodiesterase-4 (PDE4) inhibitor rolipram decreases ethanol seeking and consumption in alcohol-preferring Fawn-Hooded ratsERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertionInhibition of phosphodiesterase-4 decreases ethanol intake in miceA biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the ratGEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic dosescAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in ratsSpecific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory AcquisitionMice deficient in phosphodiesterase-4A display anxiogenic-like behaviorSystems genetic analysis of hippocampal neuroanatomy and spatial learning in mice.Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer's Dementia.PDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosisRole of cyclic nucleotide-gated channels in the modulation of mouse hippocampal neurogenesiscAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: involvement of antioxidant and anti-apoptotic mechanismsGrowth arrest and forced differentiation of human primary glioblastoma multiforme by a novel small molecule.Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress.Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's diseaseImpairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3.PI3K/AKT/mTOR signaling-mediated neuropeptide VGF in the hippocampus of mice is involved in the rapid onset antidepressant-like effects of GLYX-13.Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent mannerPhosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in MiceMemory enhancement: consolidation, reconsolidation and insulin-like growth factor 2Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth.G-protein-coupled receptors in adult neurogenesis.MEK Inhibitors Reverse cAMP-Mediated Anxiety in ZebrafishDownregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder.Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preferenceEffect of XingPiJieYu decoction on spatial learning and memory and cAMP-PKA-CREB-BDNF pathway in rat model of depression through chronic unpredictable stress
P2860
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P2860
Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Phosphodiesterase-4D knock-out ...... via increased cAMP signaling.
@en
Phosphodiesterase-4D knock-out ...... via increased cAMP signaling.
@nl
type
label
Phosphodiesterase-4D knock-out ...... via increased cAMP signaling.
@en
Phosphodiesterase-4D knock-out ...... via increased cAMP signaling.
@nl
prefLabel
Phosphodiesterase-4D knock-out ...... via increased cAMP signaling.
@en
Phosphodiesterase-4D knock-out ...... via increased cAMP signaling.
@nl
P2093
P2860
P1476
Phosphodiesterase-4D knock-out ...... via increased cAMP signaling.
@en
P2093
Han-Ting Zhang
Marco Conti
Steven P Wilson
Ying Huang
Yu-Fang Cheng
Yun-Feng Li
P2860
P304
P356
10.1523/JNEUROSCI.5236-10.2011
P407
P577
2011-01-01T00:00:00Z