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A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8E2-RING expansion of the NEDD8 cascade confers specificity to cullin modificationStructural basis for autoinhibition and phosphorylation-dependent activation of c-CblThe structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1Crystal Structure of UBA2ufd-Ubc9: Insights into E1-E2 Interactions in Sumo PathwaysBIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimerEssentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitinCasitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformationUbiquitin-like protein activation.Structure of the human histone chaperone FACT Spt16 N-terminal domain.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.Thermodynamic analysis of catalysis by the dihydroorotases from hamster and Bacillus caldolyticus, as compared with the uncatalyzed reaction.Crystallization of hamster dihydroorotase: involvement of a disulfide-linked tetrameric form.Ubiquitination Accomplished: E1 and E2 Enzymes Were Not Necessary.13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus.Structure-specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones.Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B~ubiquitin complexSynthesis and enzymic evaluation of 4-mercapto-6-oxo-1, 4-azaphosphinane-2-carboxylic acid 4-oxide as an inhibitor of mammalian dihydroorotaseDivalent metal derivatives of the hamster dihydroorotase domainBreaking up with a kinky SUMOExpression, purification, and characterization of the E1 for human NEDD8, the heterodimeric APPBP1-UBA3 complexSingle-Turnover RING/U-Box E3-Mediated Lysine Discharge AssaysIdentification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer FormationStructural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Danny T Huang
@ast
Danny T Huang
@en
Danny T Huang
@es
Danny T Huang
@nl
Danny T Huang
@sl
type
label
Danny T Huang
@ast
Danny T Huang
@en
Danny T Huang
@es
Danny T Huang
@nl
Danny T Huang
@sl
prefLabel
Danny T Huang
@ast
Danny T Huang
@en
Danny T Huang
@es
Danny T Huang
@nl
Danny T Huang
@sl
P106
P21
P31
P496
0000-0002-6192-259X