A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction.
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Protein lysine acetylation by p300/CBPFragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomainsPredictions of Ligand Selectivity from Absolute Binding Free Energy CalculationsThe photochemical thiol-ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef.CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responsesModulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112.Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.Progress in the Development of non-BET Bromodomain Chemical Probes.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Allosteric regulation of epigenetic modifying enzymes.9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomainChemical probes and inhibitors of bromodomains outside the BET family.New Approach to 1,4-Benzoxazin-3-ones by Electrochemical C-H Amination.Cation-π interactions in CREBBP bromodomain inhibition: an electrostatic model for small-molecule binding affinity and selectivity.Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment.Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple).Cation-π interactions in protein-ligand binding: theory and data-mining reveal different roles for lysine and arginine.Computer-Aided Drug Design in Epigenetics.Direct photocapture of bromodomains using tropolone chemical probes
P2860
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P2860
A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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name
A series of potent CREBBP brom ...... zed by a cation-π interaction.
@en
A series of potent CREBBP brom ...... zed by a cation-π interaction.
@nl
type
label
A series of potent CREBBP brom ...... zed by a cation-π interaction.
@en
A series of potent CREBBP brom ...... zed by a cation-π interaction.
@nl
prefLabel
A series of potent CREBBP brom ...... zed by a cation-π interaction.
@en
A series of potent CREBBP brom ...... zed by a cation-π interaction.
@nl
P2093
P2860
P50
P356
P1476
A series of potent CREBBP brom ...... zed by a cation-π interaction.
@en
P2093
Amber L Thompson
Andrew Cook
Anthony Tumber
Catherine M Rogers
David C Pryde
Duncan A Hay
Martin Philpott
Minghua Wang
Oleg Fedorov
Sarah Martin
P2860
P304
P356
10.1002/ANIE.201402750
P407
P577
2014-05-12T00:00:00Z