Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells.
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Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1.WNT7a induces E-cadherin in lung cancer cellsAutoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPKPhosphorylation regulates the subcellular location and activity of the snail transcriptional repressorThe E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression.E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer?A tale of two collagen receptors, integrin β1 and discoidin domain receptor 1, in epithelial cell differentiationDysregulation of integrin-linked kinase (ILK) signaling in colonic polyposisCorrelation of Snail expression with histological grade and lymph node status in breast carcinomasSnail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expressionThe transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulationNotch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformationWNT and beta-catenin signalling: diseases and therapiesIntegrin-linked kinase is required for epidermal and hair follicle morphogenesis.Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction - a model for cross-modulationThe small molecule inhibitor QLT0267 Radiosensitizes squamous cell carcinoma cells of the head and neck.Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation.Yin yang 1 regulates the expression of snail through a distal enhancer.Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.c-erbB2-induced disruption of matrix adhesion and morphogenesis reveals a novel role for protein kinase B as a negative regulator of alpha(2)beta(1) integrin function.Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment.Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progressionInduction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1.Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexesPancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion.Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria.Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail.Requirement of epithelial integrin-linked kinase for facilitation of Citrobacter rodentium-induced colitis.Clinicopathological significance of stromal variables: angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas.A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cellsImmunohistochemistry in melanocytic proliferative lesions.Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function.Roles of the transcription factors snail and slug during mammary morphogenesis and breast carcinoma progression.Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligasePARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expressionInterplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladder cancer through signaling ILK pathways.Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation.Differential proteomic analysis of pathway biomarkers in human breast cancer by integrated bioinformatics.Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models
P2860
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P2860
Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Inhibition of integrin linked ...... - human colon carcinoma cells.
@en
Inhibition of integrin linked ...... - human colon carcinoma cells.
@nl
type
label
Inhibition of integrin linked ...... - human colon carcinoma cells.
@en
Inhibition of integrin linked ...... - human colon carcinoma cells.
@nl
prefLabel
Inhibition of integrin linked ...... - human colon carcinoma cells.
@en
Inhibition of integrin linked ...... - human colon carcinoma cells.
@nl
P2093
P2860
P356
P1433
P1476
Inhibition of integrin linked ...... - human colon carcinoma cells.
@en
P2093
A G de Herreros
D Dominguez
J Sanghera
P Costello
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204052
P407
P577
2001-01-01T00:00:00Z
P5875
P6179
1021665373