Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.
about
P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disordersCaenorhabditis elegans neuromuscular junction: GABA receptors and ivermectin actionPharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin.ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice.Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptorsXenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes.Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.Implication of the purinergic system in alcohol use disorders.Actions of agonists, fipronil and ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytesPositive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.Expression of five acetylcholine receptor subunit genes in Brugia malayi adult wormsOral delivery of ivermectin using a fast dissolving oral film: Implications for repurposing ivermectin as a pharmacotherapy for alcohol use disorder.Ivermectin reduces alcohol intake and preference in mice.Involvement of Purinergic P2X4 Receptors in Alcohol Intake of High-Alcohol-Drinking (HAD) RatsIn vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.Pharmacological profile of Ascaris suum ACR-16, a new homomeric nicotinic acetylcholine receptor widely distributed in Ascaris tissuesAmyloid β, glutamate, excitotoxicity in Alzheimer's disease: are we on the right track?Targeting brain α7 nicotinic acetylcholine receptors in Alzheimer's disease: rationale and current status.Neonicotinoid insecticides differently modulate acetycholine-induced currents on mammalian α7 nicotinic acetylcholine receptor.Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors.Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator.Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.Monepantel is a non-competitive antagonist of nicotinic acetylcholine receptors from Ascaris suum and Oesophagostomum dentatum.
P2860
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P2860
Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Comparative pharmacology and c ...... tinic acetylcholine receptors.
@en
Comparative pharmacology and c ...... tinic acetylcholine receptors.
@nl
type
label
Comparative pharmacology and c ...... tinic acetylcholine receptors.
@en
Comparative pharmacology and c ...... tinic acetylcholine receptors.
@nl
prefLabel
Comparative pharmacology and c ...... tinic acetylcholine receptors.
@en
Comparative pharmacology and c ...... tinic acetylcholine receptors.
@nl
P2093
P1476
Comparative pharmacology and c ...... otinic acetylcholine receptors
@en
P2093
Benedict M Sattelle
Charles D Blundell
David B Sattelle
Ilse S Pienaar
Kazuhiko Matsuda
Miki Akamatsu
Steven D Buckingham
P304
P356
10.1016/J.BCP.2009.06.020
P407
P577
2009-06-21T00:00:00Z