Selective activation of adenosine A2A receptors on immune cells by a CD73-dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritis.
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A delicate balanceAdenosine kinase: exploitation for therapeutic gain.Anti-inflammatory therapy in chronic disease: challenges and opportunitiesThe Role of Purine Metabolites as DAMPs in Acute Graft-versus-Host DiseaseAdenosine receptors as drug targets--what are the challenges?Epicardium-Derived Cells Formed After Myocardial Injury Display Phagocytic Activity Permitting In Vivo Labeling and Tracking.Nucleotide signalling during inflammationA(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats.Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.Deficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis.CD73 Activity is Dispensable for the Polarization of M2 Macrophages.In-Vivo Detection and Tracking of T Cells in Various Organs in a Melanoma Tumor Model by 19F-Fluorine MRS/MRI.Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway.Dual roles of the adenosine A2a receptor in autoimmune neuroinflammationRegulation of Adenosine Deaminase on Induced Mouse Experimental Autoimmune Uveitis.Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling.CD39 and CD73 in immunity and inflammation.Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions.Correlation of low CD73 expression on synovial lymphocytes with reduced adenosine generation and higher disease severity in juvenile idiopathic arthritis.Purinergic signalling in the musculoskeletal system.Electrical stimulation enhances cell migration and integrative repair in the meniscus.Extracellular adenosine generation in the regulation of pro-inflammatory responses and pathogen colonization.Enhanced Fluorine-19 MRI Sensitivity using a Cryogenic Radiofrequency Probe: Technical Developments and Ex Vivo Demonstration in a Mouse Model of Neuroinflammation.Potential Therapeutic Applications of Adenosine A2A Receptor Ligands and Opportunities for A2A Receptor Imaging.Probing different perfluorocarbons for in vivo inflammation imaging by 19F MRI: image reconstruction, biological half-lives and sensitivity.Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors.Monocyte imaging after myocardial infarction with 19F MRI at 3 T: a pilot study in explanted porcine hearts.Anti-inflammatory effect of a novel locally acting A2A receptor agonist in a rat model of oxazolone-induced colitis.Characterization of perfluorocarbon relaxation times and their influence on the optimization of fluorine-19 MRI at 3 tesla.The Outsiders: Emerging Roles of Ectonucleotidases in InflammationThe Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases.
P2860
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P2860
Selective activation of adenosine A2A receptors on immune cells by a CD73-dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritis.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Selective activation of adenos ...... rimental rheumatoid arthritis.
@en
Selective activation of adenos ...... rimental rheumatoid arthritis.
@nl
type
label
Selective activation of adenos ...... rimental rheumatoid arthritis.
@en
Selective activation of adenos ...... rimental rheumatoid arthritis.
@nl
prefLabel
Selective activation of adenos ...... rimental rheumatoid arthritis.
@en
Selective activation of adenos ...... rimental rheumatoid arthritis.
@nl
P2093
P2860
P1476
Selective activation of adenos ...... rimental rheumatoid arthritis.
@en
P2093
Ali El-Tayeb
Christoph Jacoby
Florian Bönner
Jürgen Schrader
Lisa Galbarz
Nadine Borg
Peter L E M van Lent
Sandra Burghoff
Sandra Huels
Sebastian Temme
P2860
P304
P356
10.1126/SCITRANSLMED.3003717
P407
P577
2012-08-01T00:00:00Z