Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.
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Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid DehydrogenasesMutations of key hydrophobic surface residues of 11β-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression systemBiochemical Studies and Ligand-bound Structures of Biphenyl Dehydrogenase from Pandoraea pnomenusa Strain B-356 Reveal a Basis for Broad Specificity of the EnzymeSubstrate binding process and mechanistic functioning of type 1 11β-hydroxysteroid dehydrogenase from enhanced sampling methods.Biology-oriented synthesis.Cortisone-reductase deficiency associated with heterozygous mutations in 11beta-hydroxysteroid dehydrogenase type 1.Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissueStatic retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum.Engineering a hydroxysteroid dehydrogenase to improve its soluble expression for the asymmetric reduction of cortisone to 11β-hydrocortisone.Inhibition of 11beta-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?An in silico study on antidiabetic activity of bioactive compounds in Euphorbia thymifolia Linn.Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease16-nor Limonoids from Harrisonia perforata as promising selective 11β-HSD1 inhibitors11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.Crystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery.Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily.Retinol dehydrogenases: membrane-bound enzymes for the visual function.Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.On-column ligand exchange for structure-based drug design: a case study with human 11β-hydroxysteroid dehydrogenase type 1.Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1.The selectivity of tyrosine 280 of human 11beta-hydroxysteroid dehydrogenase type 1 in inhibitor binding.Dehydroepiandrosterone Antagonizes Pain Stress-Induced Suppression of Testosterone Production in Male Rats.Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins11β-Hydroxysteroid dehydrogenase type 1 inhibitors as therapeutic agents
P2860
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P2860
Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.
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2004 nî lūn-bûn
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2004年の論文
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name
Conformational flexibility in ...... version and enzyme regulation.
@en
Conformational flexibility in ...... version and enzyme regulation.
@nl
type
label
Conformational flexibility in ...... version and enzyme regulation.
@en
Conformational flexibility in ...... version and enzyme regulation.
@nl
prefLabel
Conformational flexibility in ...... version and enzyme regulation.
@en
Conformational flexibility in ...... version and enzyme regulation.
@nl
P2093
P2860
P921
P356
P1476
Conformational flexibility in ...... version and enzyme regulation.
@en
P2093
Andy Jennings
David J Hosfield
Gyorgy P Snell
Kathleen Aertgeerts
Mark Hilgers
Robert J Skene
P2860
P304
P356
10.1074/JBC.M411104200
P407
P577
2004-10-28T00:00:00Z