Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.
about
Pitstop 2 is a potent inhibitor of clathrin-independent endocytosisThreshold-controlled ubiquitination of the EGFR directs receptor fateRole of dynamin and clathrin in the cellular trafficking of flotillinsWASH and the Arp2/3 complex regulate endosome shape and trafficking.CAP (Cbl associated protein) regulates receptor-mediated endocytosisMICAL-like1 mediates epidermal growth factor receptor endocytosis.Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signalingEndophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.Cell signaling by receptor tyrosine kinasesSCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cellsProtein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancerProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesMembrane domain formation-a key factor for targeted intracellular drug deliveryFunctions and regulation of circular dorsal rufflesEGF receptor trafficking: consequences for signaling and cancerAPPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments.Inhomogeneity Based Characterization of Distribution Patterns on the Plasma MembraneFAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cellsDelivery of CSF-1R to the lumen of macropinosomes promotes its destruction in macrophages.ALG-2 interacting protein-X (Alix) is essential for clathrin-independent endocytosis and signalingReversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.Regulation of lysosomal ion homeostasis by channels and transportersBrassinosteroid signaling and BRI1 dynamics went undergroundAstn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration.PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalizationExtracellular lumican inhibits pancreatic cancer cell growth and is associated with prolonged survival after surgeryThe epsin protein family: coordinators of endocytosis and signalingMerlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalP130Cas attenuates epidermal growth factor (EGF) receptor internalization by modulating EGF-triggered dynamin phosphorylationLysosomal function is involved in 17β-estradiol-induced estrogen receptor α degradation and cell proliferationQuantification and kinetic analysis of Grb2-EGFR interaction on micro-patterned surfaces for the characterization of EGFR-modulating substancesRecycling of the epidermal growth factor receptor is mediated by a novel form of the clathrin adaptor protein Eps15Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerizationMolecular mechanism and physiological functions of clathrin-mediated endocytosisEndocytosis and signalling: intertwining molecular networksAssociation of Endophilin B1 with Cytoplasmic Vesicles.LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.Spatially defined EGF receptor activation reveals an F-actin-dependent phospho-Erk signaling complex.
P2860
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P2860
Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Clathrin-mediated internalizat ...... t dispensable for degradation.
@en
Clathrin-mediated internalizat ...... t dispensable for degradation.
@nl
type
label
Clathrin-mediated internalizat ...... t dispensable for degradation.
@en
Clathrin-mediated internalizat ...... t dispensable for degradation.
@nl
prefLabel
Clathrin-mediated internalizat ...... t dispensable for degradation.
@en
Clathrin-mediated internalizat ...... t dispensable for degradation.
@nl
P2093
P1433
P1476
Clathrin-mediated internalizat ...... t dispensable for degradation.
@en
P2093
Daniela Tosoni
Elena Cavallaro
Elisabetta Argenzio
Pier Paolo Di Fiore
Sara Sigismund
Simona Polo
P304
P356
10.1016/J.DEVCEL.2008.06.012
P407
P577
2008-08-01T00:00:00Z