Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.

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Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly

P2860

Q58594611-20B61D9F-565C-4837-8156-5A36B053DC88

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Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.

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Mutation-dependent aggregation ...... del for UBQLN2-associated ALS.

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Mutation-dependent aggregation ...... del for UBQLN2-associated ALS.

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label

Mutation-dependent aggregation ...... del for UBQLN2-associated ALS.

@en

Mutation-dependent aggregation ...... del for UBQLN2-associated ALS.

@nl

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Mutation-dependent aggregation ...... del for UBQLN2-associated ALS.

@en

Mutation-dependent aggregation ...... del for UBQLN2-associated ALS.

@nl

P1476

Mutation-dependent aggregation ...... del for UBQLN2-associated ALS.

@en

P2093

Joseph M Feichtmeier

http://www.w3.org/2001/XMLSchema#string

Lihong Zhan

http://www.w3.org/2001/XMLSchema#string

Lloyd M Smith

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Mark A Scalf

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Nandini Ramesh

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Randal S Tibbetts

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Sang Hwa Kim

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Shannon G Stiles

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Udai Bhan Pandey

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P2860

Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery

Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction

Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

Exome sequencing reveals VCP mutations as a cause of familial ALS

Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins

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scholarly article

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10.1093/HMG/DDX403

http://www.w3.org/2001/XMLSchema#string

P577

2017-11-17T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

29161404

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P921

amyotrophic lateral sclerosis

Drosophila

P932

5886165

http://www.w3.org/2001/XMLSchema#string

Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.

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P2860

P2860

Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.

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P1433

P1476

P2093

P2860

P31

P356

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P31

P356

P577

P698

P921

P932