Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice.
about
From bending DNA to diabetes: the curious case of HMGA1The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and functionInflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's DiseaseMolecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell DysfunctionRNA-Mediated Regulation of HMGA1 FunctionHigh mobility group a proteins as tumor markersRecent advances in the molecular genetics of type 2 diabetes mellitusMénage à Trois in stress: DAMPs, redox and autophagyCrystal structure of a complex of DNA with one AT-hook of HMGA1HMGA1-pseudogenes and cancerA versatile nanotrap for biochemical and functional studies with fluorescent fusion proteinsTranscriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic miceParafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult miceHMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathwayMapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line.Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD).Resequencing PNMT in European hypertensive and normotensive individuals: no common susceptibilily variants for hypertension and purifying selection on intron 1.Genomic characterisation, chromosomal assignment and in vivo localisation of the canine high mobility group A1 (HMGA1) gene.The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasisHmga1/Hmga2 double knock-out mice display a "superpygmy" phenotypeThe High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake.HMG modifications and nuclear function.New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents.HMGA1 down-regulation is crucial for chromatin composition and a gene expression profile permitting myogenic differentiationA New Gene Expression Signature for Triple Negative Breast Cancer Using Frozen Fresh Tissue before Neoadjuvant Chemotherapy.HMGB1 in health and disease.Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets.High mobility group A: a novel biomarker and therapeutic target in pancreatic adenocarcinoma.Molecular mechanisms of insulin resistance in type 2 diabetes mellitusRegulation of microRNA expression by HMGA1 proteins.Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct-1 and Oct-2.New genetic loci link adipose and insulin biology to body fat distribution.A novel mechanism of post-translational modulation of HMGA functions by the histone chaperone nucleophosmin.Potential benefits of berberine in the management of perimenopausal syndrome.The Association between HMGA1 rs146052672 Variant and Type 2 Diabetes: A Transethnic Meta-Analysis.Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms.The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA RepairPopulation PK/PD analysis of metformin using the signal transduction model.Mutation of cysteine 46 in IKK-beta increases inflammatory responses.
P2860
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P2860
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Lack of the architectural fact ...... d diabetes in humans and mice.
@en
Lack of the architectural fact ...... d diabetes in humans and mice.
@nl
type
label
Lack of the architectural fact ...... d diabetes in humans and mice.
@en
Lack of the architectural fact ...... d diabetes in humans and mice.
@nl
prefLabel
Lack of the architectural fact ...... d diabetes in humans and mice.
@en
Lack of the architectural fact ...... d diabetes in humans and mice.
@nl
P2093
P2860
P50
P356
P1433
P1476
Lack of the architectural fact ...... d diabetes in humans and mice.
@en
P2093
Guidalberto Manfioletti
Leonardo Brunetti
Rodolfo Iuliano
P2860
P2888
P304
P356
10.1038/NM1254
P407
P50
P577
2005-05-29T00:00:00Z