Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
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Structures of RNA polymerase-antibiotic complexesResponse to Klyuyev and Vassylyev: on the mechanism of tagetitoxin inhibition of transcriptionRifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active centerStructural basis for transcription inhibition by tagetitoxinStructural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocationX-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with BenzoxazinorifamycinsThe RNA polymerase-binding protein RbpA confers basal levels of rifampicin resistance on Streptomyces coelicolorAn Ebola virus-centered knowledge baseAvoidable errors in deposited macromolecular structures: an impediment to efficient data mining.A structural model of the E. coli PhoB dimer in the transcription initiation complex.Central role of the RNA polymerase trigger loop in intrinsic RNA hydrolysis.Multicenter study for defining the breakpoint for rifampin resistance in Neisseria meningitidis by rpoB sequencing.Allosteric supramolecular triple-layer catalysts.The evolving role of chemical synthesis in antibacterial drug discovery.A docking-based receptor library of antibiotics and its novel application in predicting chronic mixture toxicity for environmental risk assessment.Modulation of RNA polymerase activity through the trigger loop foldingStructural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.Structural biology of bacterial RNA polymerase.Chemical synthesis enables biochemical and antibacterial evaluation of streptolydigin antibiotics.MicroRNA signatures from multidrug‑resistant Mycobacterium tuberculosis.Structural perspective on mutations affecting the function of multisubunit RNA polymerases.RNA polymerase III subunit architecture and implications for open promoter complex formation.Bacterial Transcription as a Target for Antibacterial Drug Development.Computational simulation strategies for analysis of multisubunit RNA polymerases.RNA polymerase active center: the molecular engine of transcription.Macromolecular micromovements: how RNA polymerase translocates.Elongation by RNA polymerase: a race through roadblocks.CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase.Rifaximin: a nonsystemic rifamycin antibiotic for gastrointestinal infections.The structures of type I polyketide synthases.Basic mechanism of transcription by RNA polymerase II.Total synthesis of antibiotics: recent achievements, limitations, and perspectives.Distinct functions of the RNA polymerase σ subunit region 3.2 in RNA priming and promoter escape.Comparative microbiological studies of transcription inhibitors fidaxomicin and the rifamycins in Clostridium difficileIn vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.On the validation of crystallographic symmetry and the quality of structures.Mutations in the CRE pocket of bacterial RNA polymerase affect multiple steps of transcription.Assessment of the Efficacy of New Anti-Tuberculosis Drugs.The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic siteModification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis.
P2860
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P2860
Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Allosteric modulation of the R ...... ription control by rifamycins.
@en
Allosteric modulation of the R ...... ription control by rifamycins.
@nl
type
label
Allosteric modulation of the R ...... ription control by rifamycins.
@en
Allosteric modulation of the R ...... ription control by rifamycins.
@nl
prefLabel
Allosteric modulation of the R ...... ription control by rifamycins.
@en
Allosteric modulation of the R ...... ription control by rifamycins.
@nl
P2093
P1433
P1476
Allosteric modulation of the R ...... ription control by rifamycins.
@en
P2093
Anna Perederina
Dmitri Svetlov
Dmitry G Vassylyev
Irina Artsimovitch
Marina N Vassylyeva
Naohiro Matsugaki
Noriyuki Igarashi
Soichi Wakatsuki
Tahir H Tahirov
Vladimir Svetlov
P304
P356
10.1016/J.CELL.2005.07.014
P407
P577
2005-08-01T00:00:00Z