Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.

Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.

Item
http://www.wikidata.org/entity/Q46798082
Structure-based methods for predicting target mutation-induced drug resistance and rational drug design to overcome the problemLersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 12-Hy-droxy-N-(3-nitro-phen-yl)benzamide.5-Chloro-2-hy-droxy-benzoic acid.New in silico and conventional in vitro approaches to advance HIV drug discovery and design.Extensive mutagenesis of the conserved box E motif in duck hepatitis B virus P protein reveals multiple functions in replication and a common structure with the primer grip in HIV-1 reverse transcriptaseMechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates.Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2).Comparison of the non-nucleoside reverse transcriptase inhibitor lersivirine with its pyrazole and imidazole isomers.Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.
P2860

Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.

Item
http://www.wikidata.org/entity/Q46798082
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Specific targeting highly cons ...... NRTIs with antiviral activity.
@en
Specific targeting highly cons ...... NRTIs with antiviral activity.
@nl
type
label
Specific targeting highly cons ...... NRTIs with antiviral activity.
@en
Specific targeting highly cons ...... NRTIs with antiviral activity.
@nl
prefLabel
Specific targeting highly cons ...... NRTIs with antiviral activity.
@en
Specific targeting highly cons ...... NRTIs with antiviral activity.
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
Specific targeting highly cons ...... NRTIs with antiviral activity.
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698