The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.
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Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradationAnnexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levelsFurin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytesCripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturationAngiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertasesIn vivo evidence that furin from hepatocytes inactivates PCSK9Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanaseAutocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site.Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration.The role of furin in papillomavirus infection.The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolismProprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasisImaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.Proprotein convertases process Pmel17 during secretion.Embryo implantation is closely associated with dynamic expression of proprotein convertase 5/6 in the rabbit uterus.Molecular Validation of PACE4 as a Target in Prostate CancerThe paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2).Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants.Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.Opposite roles of furin and PC5A in N-cadherin processing.Anti-neurotrophic effects from autoantibodies in adult diabetes having primary open angle glaucoma or dementiaThe proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding.The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol.Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression.Proteolytic cleavage of the hydrophobic domain in the CaVα2δ1 subunit improves assembly and activity of cardiac CaV1.2 channels.Proprotein convertase 5/6a is associated with bone morphogenetic protein-2-induced squamous cell differentiation.The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.The protease-associated domain and C-terminal extension are required for zymogen processing, sorting within the secretory pathway, and activity of tomato subtilase 3 (SlSBT3).Fell-Muir Lecture: Fibrillin microfibrils: structural tensometers of elastic tissues?Zymogen activation of neurotrypsin and neurotrypsin-dependent agrin cleavage on the cell surface are enhanced by glycosaminoglycans.Functional analysis of corin protein domains required for PCSK6-mediated activation.Thrombin activation of protein C requires prior processing by a liver proprotein convertase.Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice.
P2860
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P2860
The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
The regulated cell surface zym ...... g of its secretory substrates.
@en
The regulated cell surface zym ...... g of its secretory substrates.
@nl
type
label
The regulated cell surface zym ...... g of its secretory substrates.
@en
The regulated cell surface zym ...... g of its secretory substrates.
@nl
prefLabel
The regulated cell surface zym ...... g of its secretory substrates.
@en
The regulated cell surface zym ...... g of its secretory substrates.
@nl
P2093
P2860
P356
P1476
The regulated cell surface zym ...... g of its secretory substrates.
@en
P2093
Edwidge Marcinkiewicz
Gaétan Mayer
Josée Hamelin
Marie-Claude Asselin
Meiyi Tang
Siamak Tabibzadeh
P2860
P304
P356
10.1074/JBC.M708763200
P407
P577
2007-11-26T00:00:00Z