Designing and producing modified, new-to-nature peptides with antimicrobial activity by use of a combination of various lantibiotic modification enzymes.
about
Antimicrobial Peptide Resistance Mechanisms of Gram-Positive Bacteria.Structure and mechanism of lanthipeptide biosynthetic enzymes.Pseudomycoicidin, a Class II Lantibiotic from Bacillus pseudomycoides.Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy AcidPost-translational Introduction of D-Alanine into Ribosomally Synthesized Peptides by the Dehydroalanine Reductase NpnJNew Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products.In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide ThiomuracinAdvances in the arsenal of tools available enabling the discovery of novel lantibiotics with therapeutic potential.Potentiating the Activity of Nisin against Escherichia coli.Employing the promiscuity of lantibiotic biosynthetic machineries to produce novel antimicrobials.Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.Incorporation of tryptophan analogues into the lantibiotic nisin.Lantibiotic Reductase LtnJ Substrate Selectivity Assessed with a Collection of Nisin Derivatives as Substrates.Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products.Identification of essential amino acid residues in the nisin dehydratase NisB.Zirex: a novel zinc-regulated expression system for Lactococcus lactis.In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products.BAGEL3: Automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides.The length of a lantibiotic hinge region has profound influence on antimicrobial activity and host specificityGenome-guided identification of novel head-to-tail cyclized antimicrobial peptides, exemplified by the discovery of pumilarin.Ribosomal Natural Products, Tailored To Fit.Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.Insight into Two ABC Transporter Families Involved in Lantibiotic Resistance.Specificity and Application of the Lantibiotic Protease NisP.Carboxyl Analogue of Mutacin 1140, a Scaffold for Lead Antibacterial Discovery.Expanding the Genetic Code of Lactococcus lactis and Escherichia coli to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics.The biosynthesis of methanobactin.Perspectives on lantibiotic discovery - where have we failed and what improvements are required?Isolation and characterization of Bacillus sp. GFP-2, a novel Bacillus strain with antimicrobial activities, from Whitespotted bamboo shark intestine.Heterologous Production of Microbial Ribosomally Synthesized and Post-translationally Modified Peptides
P2860
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P2860
Designing and producing modified, new-to-nature peptides with antimicrobial activity by use of a combination of various lantibiotic modification enzymes.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
Designing and producing modifi ...... tibiotic modification enzymes.
@en
Designing and producing modifi ...... tibiotic modification enzymes.
@nl
type
label
Designing and producing modifi ...... tibiotic modification enzymes.
@en
Designing and producing modifi ...... tibiotic modification enzymes.
@nl
prefLabel
Designing and producing modifi ...... tibiotic modification enzymes.
@en
Designing and producing modifi ...... tibiotic modification enzymes.
@nl
P2093
P356
P1476
Designing and producing modifi ...... ntibiotic modification enzymes
@en
P2093
Auke J van Heel
Djoke Hendriks
Oscar P Kuipers
P304
P356
10.1021/SB3001084
P577
2013-02-12T00:00:00Z