Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss.
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p53 activation by knockdown technologiesZebrafish models of TauopathyCan zebrafish be used as animal model to study Alzheimer's disease?SiO2 nanoparticles change colour preference and cause Parkinson's-like behaviour in zebrafish.p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent mannerPhenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors.High-throughput screening and small animal models, where are we?Animal models in the drug discovery pipeline for Alzheimer's diseaseAll-trans-retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by downregulating p53 expressionPropylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-SecretaseIncreased DJ-1 expression under oxidative stress and in Alzheimer's disease brains.Presenilin: RIP and beyond.Aspects of beta-amyloid as a biomarker for Alzheimer's disease.p53 is balancing development, differentiation and de-differentiation to assure cancer prevention.Zebrafish as a model to understand autophagy and its role in neurological disease.Modeling human neurodegenerative diseases in transgenic systems.Using the zebrafish model for Alzheimer's disease research.Analysis of sexually dimorphic expression of genes at early gonadogenesis of pejerrey Odontesthes bonariensis using a heterologous microarray.Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ1-42 and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae.Zebrafish models in neuropsychopharmacology and CNS drug discovery.MicroRNA-125b is a novel negative regulator of p53.Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity.p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity.Tetracapsuloides bryosalmonae infection affects the expression of genes involved in cellular signal transduction and iron metabolism in the kidney of the brown trout Salmo trutta.Analysis of nicastrin gene phylogeny and expression in zebrafish.P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer's amyloid reducing gamma-secretase inhibitors.A high-throughput analysis method to detect regions of interest and quantify zebrafish embryo images.Automated quantification of zebrafish somites based on PDE method.The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis.p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease.Zebrafish: an emerging real-time model system to study Alzheimer's disease and neurospecific drug discoveryStimulation of p53 Transactivation Ability by Nicastrin in Mouse Fibroblasts
P2860
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P2860
Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Zebrafish lacking Alzheimer pr ...... t apoptosis and neuronal loss.
@en
Zebrafish lacking Alzheimer presenilin enhancer 2
@nl
type
label
Zebrafish lacking Alzheimer pr ...... t apoptosis and neuronal loss.
@en
Zebrafish lacking Alzheimer presenilin enhancer 2
@nl
prefLabel
Zebrafish lacking Alzheimer pr ...... t apoptosis and neuronal loss.
@en
Zebrafish lacking Alzheimer presenilin enhancer 2
@nl
P2093
P2860
P1476
Zebrafish lacking Alzheimer pr ...... t apoptosis and neuronal loss.
@en
P2093
Hongwei Yang
Jacqueline A Sears
Stephen T C Wong
Tao P Zhong
Tianming Liu
Weiming Xia
William A Campbell
P2860
P304
P356
10.1111/J.1471-4159.2006.03648.X
P407
P577
2006-02-08T00:00:00Z