Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.
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MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomesIn vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane trafficPhosphoinositides: tiny lipids with giant impact on cell regulationMTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegansLoss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafishStructure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidationThe PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activityAAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasisThe inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4Identification of PTPsigma as an autophagic phosphatase.Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis.Cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development in zebrafishThe role of PI3P phosphatases in the regulation of autophagyMembrane traffic and muscle: lessons from human diseaseGenomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIalpha and IIbeta and a partial nuclear localization of the IIalpha isoform.Expression, purification, crystallization and preliminary crystallographic analysis of human myotubularin-related protein 3Crystallization and preliminary X-ray crystallographic analysis of the PH-GRAM domain of human MTMR4Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis.The myotubularin family of lipid phosphatases in disease and in spermatogenesisMyotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling.Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins.Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice.The CMT4B disease-causing phosphatases Mtmr2 and Mtmr13 localize to the Schwann cell cytoplasm and endomembrane compartments, where they depend upon each other to achieve wild-type levels of protein expression.Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.An Emerging Role for PI5P in T Cell Biology.Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking.Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of DiabetesProtein tyrosine phosphatases: dual-specificity phosphatases in health and disease.MTMR4 Is Required for the Stability of the Salmonella-Containing VacuoleFunction and dysfunction of the PI system in membrane trafficking.The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signallingPhosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling.A phosphoinositide conversion mechanism for exit from endosomes.Multiple disease-linked myotubularin mutations cause NFL assembly defects in cultured cells and disrupt myotubularin dimerization.PI(3;5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membranePI3P is dephosphorylated to PI by MTM proteins at the early endosome membranePI(3;5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane
P2860
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P248
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P2860
Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Systematic analysis of myotubu ...... nd endosome related functions.
@en
Systematic analysis of myotubu ...... nd endosome related functions.
@nl
type
label
Systematic analysis of myotubu ...... nd endosome related functions.
@en
Systematic analysis of myotubu ...... nd endosome related functions.
@nl
prefLabel
Systematic analysis of myotubu ...... nd endosome related functions.
@en
Systematic analysis of myotubu ...... nd endosome related functions.
@nl
P50
P921
P356
P1476
Systematic analysis of myotubu ...... nd endosome related functions.
@en
P304
P356
10.1242/JCS.03040
P407
P577
2006-06-20T00:00:00Z