Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.
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Substrate specificity of the ubiquitin and Ubl proteasesUbiquitin modificationsTNF biology, pathogenic mechanisms and emerging therapeutic strategiesRegulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULINDeubiquitinating enzymes in cellular signaling and disease regulationMolecular basis for specificity of the Met1-linked polyubiquitin signalLinear ubiquitination in immunityCYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune SignalingHTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin ChainsThe tumour suppressor CYLD regulates the p53 DNA damage responseUSP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian ClockRestricting the ψ Torsion Angle Has Stereoelectronic Consequences on a Scissile Bond: An Electronic Structure Analysis.Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease.Formation and removal of poly-ubiquitin chains in the regulation of tumor necrosis factor-induced gene activation and cell death.CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different.Linear ubiquitin chains: enzymes, mechanisms and biologySPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC SignalingLinear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.The B-box module of CYLD is responsible for its intermolecular interaction and cytoplasmic localization.Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation.Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.Mechanism and regulation of the Lys6-selective deubiquitinase USP30.Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30.Functional analysis of the C. elegans cyld-1 gene reveals extensive similarity with its human homolog.Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168.Modulating inflammation through the negative regulation of NF-κB signaling.Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes.Structural insights into ubiquitin phosphorylation by PINK1The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel
P2860
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P2860
Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年学术文章
@wuu
2015年学术文章
@zh
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh-hant
name
Structures of CYLD USP with Me ...... chanisms for dual specificity.
@en
Structures of CYLD USP with Me ...... chanisms for dual specificity.
@nl
type
label
Structures of CYLD USP with Me ...... chanisms for dual specificity.
@en
Structures of CYLD USP with Me ...... chanisms for dual specificity.
@nl
prefLabel
Structures of CYLD USP with Me ...... chanisms for dual specificity.
@en
Structures of CYLD USP with Me ...... chanisms for dual specificity.
@nl
P2093
P2860
P356
P1476
Structures of CYLD USP with Me ...... echanisms for dual specificity
@en
P2093
Atsushi Yamagata
Jun-ichiro Inoue
Keiko Kubota
Sakurako Goto-Ito
Shuya Fukai
Yuji Kubota
Yuri Shibata
Yusuke Sato
P2860
P2888
P304
P356
10.1038/NSMB.2970
P577
2015-02-16T00:00:00Z