Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.

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Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.Leucine rich repeat kinase knockout (LRRK KO) mouse model: Linking pathological hallmarks of inherited and sporadic Parkinson's disease.

P2860

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P2860

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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name

Age-Dependent Dopaminergic Neu ...... athway in LRRK-Deficient Mice.

@en

Age-Dependent Dopaminergic Neu ...... athway in LRRK-Deficient Mice.

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type

Item

label

Age-Dependent Dopaminergic Neu ...... athway in LRRK-Deficient Mice.

@en

Age-Dependent Dopaminergic Neu ...... athway in LRRK-Deficient Mice.

@nl

prefLabel

Age-Dependent Dopaminergic Neu ...... athway in LRRK-Deficient Mice.

@en

Age-Dependent Dopaminergic Neu ...... athway in LRRK-Deficient Mice.

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P1476

Age-Dependent Dopaminergic Neu ...... athway in LRRK-Deficient Mice.

@en

P2093

Emilie Giaime

http://www.w3.org/2001/XMLSchema#string

Guodong Huang

http://www.w3.org/2001/XMLSchema#string

Jie Shen

http://www.w3.org/2001/XMLSchema#string

Lisa K Wagner

http://www.w3.org/2001/XMLSchema#string

Yang Yuan

http://www.w3.org/2001/XMLSchema#string

Youren Tong

http://www.w3.org/2001/XMLSchema#string

P2860

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Genome-wide association study reveals genetic risk underlying Parkinson's disease

Formation process of autophagosome is traced with Apg8/Aut7p in yeast

Alpha-synuclein in Lewy bodies

LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectives

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

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796-807.e6

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scholarly article

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10.1016/J.NEURON.2017.09.036

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English

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2017-10-18T00:00:00Z

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dopamine

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Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.

about

P2860

P2860

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.

description

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