about
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligasePhosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destructionCharacterization of a novel isoform of murine interferon regulatory factor 3Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammalsSIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylationAcetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminusSCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destructionAkt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair.Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.The two faces of FBW7 in cancer drug resistance.SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.DEPTOR ubiquitination and destruction by SCF(β-TrCP).SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradationSCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis.Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7.Phosphorylation of Rictor at Thr1135 impairs the Rictor/Cullin-1 complex to ubiquitinate SGK1.Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1.FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A.Extracellular Signal-regulated Kinases (ERKs) Phosphorylate Lin28a Protein to Modulate P19 Cell Proliferation and Differentiation.Over-expression and purification of isotopically labeled recombinant ligand-binding domain of orphan nuclear receptor human B1-binding factor/human liver receptor homologue 1 for NMR studies.Presensitized immune condition of host exaggerates prolonged cold ischemia-mediated injury of cardiac graft involving regulatory T cells.The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168.Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.Experimental approaches to investigate the proteasomal degradation pathways involved in regulation of apoptosis.Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.Identification of recurrent USP48 and BRAF mutations in Cushing's diseaseReplyCUL5-SOCS6 complex regulates mTORC2 function by targeting Sin1 for degradation
P50
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P50
description
onderzoeker
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researcher
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հետազոտող
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name
Daming Gao
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Daming Gao
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Daming Gao
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Daming Gao
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Daming Gao
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Daming Gao
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Daming Gao
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Daming Gao
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Daming Gao
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Daming Gao
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D M Gao
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Daming Gao
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Gao D M
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Gao Daming
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Daming Gao
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Daming Gao
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Daming Gao
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Daming Gao
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Daming Gao
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P106
P31
P496
0000-0003-4374-1055