Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. - Test2 - elhamkhani - TriplyDB

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

http://www.wikidata.org/entity/Q35619339

about

CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradation Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis Cadherin-mediated cell-cell adhesion and signaling in the skeleton APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.Gene-set based genome-wide association analysis for the speed of sound in two skeletal sites of Korean women.Targeting Cdc20 as a novel cancer therapeutic strategy.The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid.Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling Smurf1 regulation of DAB2IP controls cell proliferation and migration SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging.CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes.Ubiquitylation of active Rac1 by the E3 ubiquitin-ligase HACE1.A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.E3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics.The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myeloma.Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis.Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch.Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.

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Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

http://www.wikidata.org/entity/Q35619339

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

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Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

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type

label

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

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Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

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prefLabel

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

@ast

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

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J.MOLCEL.2011.09.024

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Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

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Anders H Berg

http://www.w3.org/2001/XMLSchema#string

Chantel Lester

http://www.w3.org/2001/XMLSchema#string

Dorothy Hu

http://www.w3.org/2001/XMLSchema#string

Hidefumi Fukushima

http://www.w3.org/2001/XMLSchema#string

Hiroyuki Inuzuka

http://www.w3.org/2001/XMLSchema#string

Laurie H Glimcher

http://www.w3.org/2001/XMLSchema#string

Lixin Wan

http://www.w3.org/2001/XMLSchema#string

Rebecca Drapp

http://www.w3.org/2001/XMLSchema#string

Shavali Shaik

http://www.w3.org/2001/XMLSchema#string

Weiguo Zou

http://www.w3.org/2001/XMLSchema#string

P2860

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC.

Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1

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721-733

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scholarly article

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5

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44

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Marcos Malumbres

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2011-12-01T00:00:00Z

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51862703

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22152476

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3240853

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