Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
about
CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradationStructural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β PathwaysRegulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin LigasesFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisCadherin-mediated cell-cell adhesion and signaling in the skeletonAPC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathwayThe E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult miceSelective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradationAPC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.Gene-set based genome-wide association analysis for the speed of sound in two skeletal sites of Korean women.Targeting Cdc20 as a novel cancer therapeutic strategy.The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent mannerCdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid.Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in ratsSmurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signalingSmurf1 regulation of DAB2IP controls cell proliferation and migrationSCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging.CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes.Ubiquitylation of active Rac1 by the E3 ubiquitin-ligase HACE1.A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.E3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics.The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myeloma.Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis.Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch.Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.
P2860
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P2860
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
@ast
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
@en
type
label
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
@ast
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
@en
prefLabel
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
@ast
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
@en
P2093
P2860
P50
P1433
P1476
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
@en
P2093
Anders H Berg
Chantel Lester
Dorothy Hu
Hidefumi Fukushima
Hiroyuki Inuzuka
Laurie H Glimcher
Rebecca Drapp
Shavali Shaik
Weiguo Zou
P2860
P304
P356
10.1016/J.MOLCEL.2011.09.024
P577
2011-12-01T00:00:00Z