Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin.
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Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer diseaseSenile plaque neurites in Alzheimer disease accumulate amyloid precursor proteinCysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsMyosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament densityEvidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease.Roles of tau protein in health and disease.Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death.Protective mechanisms by cystatin C in neurodegenerative diseases.Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet.Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagyCalpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's diseaseSubcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice.Normal processing of the Alzheimer's disease amyloid beta protein precursor generates potentially amyloidogenic carboxyl-terminal derivatives.Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein.Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathologyEndocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's diseaseMicroarray expression analysis and identification of serum biomarkers for Niemann-Pick disease, type C1.Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy.Endolysosome involvement in LDL cholesterol-induced Alzheimer's disease-like pathology in primary cultured neurons.Processing of the Alzheimer's disease beta A4 amyloid protein precursor (APP).Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice.Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease.Cystatin C in aging and in Alzheimer's disease.Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer's Disease.The lysosomal system in neuronal cell death: a review.Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors.Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease.Proteolysis of microtubule-associated protein 2 and tubulin by cathepsin D.Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain.Lysosomal amino acid transporter LYAAT-1 in the rat central nervous system: an in situ hybridization and immunohistochemical study.Association between cathepsin D polymorphism and Alzheimer's disease in a Chinese Han population.Laminin and its neurite outgrowth-promoting domain in the brain in Alzheimer's disease and Down's syndrome patients.Taking out the garbage: cathepsin D and calcineurin in neurodegeneration.Autophagocytosis of mitochondria is prominent in Alzheimer disease.Intracellular accumulation of insoluble, newly synthesized abetan-42 in amyloid precursor protein-transfected cells that have been treated with Abeta1-42.
P2860
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P2860
Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh-hant
name
Lysosomal proteinase antigens ...... vidence for a neuronal origin.
@en
Lysosomal proteinase antigens ...... vidence for a neuronal origin.
@nl
type
label
Lysosomal proteinase antigens ...... vidence for a neuronal origin.
@en
Lysosomal proteinase antigens ...... vidence for a neuronal origin.
@nl
prefLabel
Lysosomal proteinase antigens ...... vidence for a neuronal origin.
@en
Lysosomal proteinase antigens ...... vidence for a neuronal origin.
@nl
P2093
P1433
P1476
Lysosomal proteinase antigens ...... vidence for a neuronal origin.
@en
P2093
P304
P356
10.1016/0006-8993(90)90456-L
P407
P577
1990-04-01T00:00:00Z