about
Twenty proteins containing a C-terminal SOCS box form five structural classesAnkyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradationRegulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardationFunctional analysis of Asb-1 using genetic modification in miceERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specificationThrombocytopenia and kidney disease in mice with a mutation in the C1galt1 geneAlpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptorProduction of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1The pseudokinase MLKL mediates necroptosis via a molecular switch mechanismAdaptor protein SKAP55R is associated with myeloid differentiation and growth arrestGrowth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)The SOCS box: a tale of destruction and degradationDistinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transductionThe transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cellsSmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivationSuppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signalingMurine cerberus homologue mCer-1: a candidate anterior patterning moleculeMutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities.Proximal genomic localization of STAT1 binding and regulated transcriptional activityPolycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activitySynergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors.A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopeniaDual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain.Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptorSuppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.Estimating the proportion of microarray probes expressed in an RNA sample.Critical roles for c-Myb in lymphoid priming and early B-cell developmentPolycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexesDeficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice.Inhibitors of cytokine signal transduction.Regulation of hematopoietic stem cells by their mature progenyDonald Metcalf (1929-2014).NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
ricercatore
@it
հետազոտող
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name
Douglas J Hilton
@nl
Douglas J Hilton
@sl
Douglas J. Hilton
@en
Douglas J. Hilton
@es
type
label
Douglas J Hilton
@nl
Douglas J Hilton
@sl
Douglas J. Hilton
@en
Douglas J. Hilton
@es
altLabel
Hilton DJ
@en
prefLabel
Douglas J Hilton
@nl
Douglas J Hilton
@sl
Douglas J. Hilton
@en
Douglas J. Hilton
@es
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P1053
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P3829
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0000-0002-7698-2392
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P7859
lccn-n97024272