about
Lessons learned from the transformation of natural product discovery to a genome-driven endeavorStructure, Bioactivity, and Resistance Mechanism of Streptomonomicin, an Unusual Lasso Peptide from an Understudied Halophilic ActinomyceteAntibacterial drug leads targeting isoprenoid biosynthesisStructural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesisHIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid BiosynthesisThioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteineSubcellular targeting and differential S-nitrosylation of endothelial nitric-oxide synthase.Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor familyMultitarget drug discovery for tuberculosis and other infectious diseases.Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads.Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum.Thiazole/oxazole-modified microcins: complex natural products from ribosomal templatesDiscovery of a new ATP-binding motif involved in peptidic azoline biosynthesis.Nucleophilic 1,4-additions for natural product discovery.Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.HIV protease inhibitors block streptolysin S productionIdentification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products.Discovery of a widely distributed toxin biosynthetic gene cluster.Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family.Minimum Information about a Biosynthetic Gene cluster.The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles.A prevalent peptide-binding domain guides ribosomal natural product biosynthesis.Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells.Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicinCrystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolidCrystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168.Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis.In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide ThiomuracinTargeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid DiagnosticsEngineering unnatural variants of plantazolicin through codon reprogramming.Synthesis of plantazolicin analogues enables dissection of ligand binding interactions of a highly selective methyltransferaseStreptolysin S-like virulence factors: the continuing sagA.Orchestration of enzymatic processing by thiazole/oxazole-modified microcin dehydrogenases.Profiling of Microbial Colonies for High-Throughput Engineering of Multistep Enzymatic Reactions via Optically Guided Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.A new genome-mining tool redefines the lasso peptide biosynthetic landscape.Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S.Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea.Design and characterization of an active site selective caspase-3 transnitrosating agent.Catalase-peroxidase activity of iron(III)-TAML activators of hydrogen peroxide.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Douglas A Mitchell
@ast
Douglas A Mitchell
@en
Douglas A Mitchell
@es
Douglas A Mitchell
@nl
Douglas A Mitchell
@sl
دوغلاس أ ميتشيل
@ar
type
label
Douglas A Mitchell
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Douglas A Mitchell
@en
Douglas A Mitchell
@es
Douglas A Mitchell
@nl
Douglas A Mitchell
@sl
دوغلاس أ ميتشيل
@ar
prefLabel
Douglas A Mitchell
@ast
Douglas A Mitchell
@en
Douglas A Mitchell
@es
Douglas A Mitchell
@nl
Douglas A Mitchell
@sl
دوغلاس أ ميتشيل
@ar
P106
P21
P31
P496
0000-0002-9564-0953