Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.
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The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta.Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated propertiesAberrant expression of the transcription factors snail and slug alters the response to genotoxic stressTransforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transitionAutocrine PDGFR signaling promotes mammary cancer metastasisExpression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activitiesPKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancersThe Spemann organizer gene, Goosecoid, promotes tumor metastasisCommon ground in the transcriptional profiles of wounds and tumorsInvestigation of three new mouse mammary tumor cell lines as models for transforming growth factor (TGF)-beta and Neu pathway signaling studies: identification of a novel model for TGF-beta-induced epithelial-to-mesenchymal transitionSirtuins and Cancer: Role in the Epithelial-Mesenchymal TransitionMesenchymal Stem Cell-Mediated Effects of Tumor Support or SuppressionLinking epithelial-to-mesenchymal-transition and epigenetic modificationsEpithelial-mesenchymal plasticity in carcinoma metastasisE-cadherin's dark side: possible role in tumor progressionMEK5/ERK5 pathway: the first fifteen yearsTargeting the epithelial to mesenchymal transition in glioblastoma: the emerging role of MET signalingRAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expressionNeuraminidase-1: a novel therapeutic target in multistage tumorigenesisRegulation of epithelial-mesenchymal transition through epigenetic and post-translational modificationsEpithelial-Mesenchymal Plasticity: A Central Regulator of Cancer ProgressionmiR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasisTGF-β-induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loopsRAS oncogenes: weaving a tumorigenic webThe Regulatory Role of MicroRNAs in EMT and CancerThe role of T‑box genes in the tumorigenesis and progression of cancer (Review)JAM-C regulates tight junctions and integrin-mediated cell adhesion and migrationTGF-beta-induced epithelial to mesenchymal transitionEvaluation of molecular markers of mesenchymal phenotype in melanoma.Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells.Transforming growth factor beta controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin.Cyfip1 is a putative invasion suppressor in epithelial cancers.E-cadherin suppression directs cytoskeletal rearrangement and intraepithelial tumor cell migration in 3D human skin equivalents.RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.Low concentrations of transforming growth factor-beta-1 induce tubulogenesis in cultured mammary epithelial cells.TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status.Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumorsRegulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction.
P2860
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P2860
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Diverse cellular and molecular ...... ial plasticity and metastasis.
@en
Diverse cellular and molecular ...... ial plasticity and metastasis.
@nl
type
label
Diverse cellular and molecular ...... ial plasticity and metastasis.
@en
Diverse cellular and molecular ...... ial plasticity and metastasis.
@nl
prefLabel
Diverse cellular and molecular ...... ial plasticity and metastasis.
@en
Diverse cellular and molecular ...... ial plasticity and metastasis.
@nl
P356
P1476
Diverse cellular and molecular ...... lial plasticity and metastasis
@en
P2093
Hartmut Beug
Stefan Grünert
P2888
P304
P356
10.1038/NRM1175
P577
2003-08-01T00:00:00Z