Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
about
From bending DNA to diabetes: the curious case of HMGA1Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiaDeletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinaseNicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells.Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretionInvolvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucoseDysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetesJunctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose toleranceNuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cellsInsulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeSirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cellsVisceral adiposity syndromeSuppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-CellsUsing Drosophila to discover mechanisms underlying type 2 diabetesThe mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseasesRedox homeostasis in pancreatic β cellsPost-transcriptional regulation in metabolic diseasesA genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretionFibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in PancreasNatural history of β-cell adaptation and failure in type 2 diabetesInsulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cellsIdentifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetesThe Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cellsTissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemiaFunctional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetesInsulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathwaysBrown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistancePreptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretionBeta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intoleranceThe forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growthMembers of the large Maf transcription family regulate insulin gene transcription in islet beta cellsEffects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistanceThe MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.Role of the transcription factor sox4 in insulin secretion and impaired glucose toleranceClass II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cellsCoordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cellsBlockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretionInsulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cellsGenetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number
P2860
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P2860
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Tissue-specific knockout of th ...... ar to that in type 2 diabetes.
@en
Tissue-specific knockout of th ...... ar to that in type 2 diabetes.
@nl
type
label
Tissue-specific knockout of th ...... ar to that in type 2 diabetes.
@en
Tissue-specific knockout of th ...... ar to that in type 2 diabetes.
@nl
prefLabel
Tissue-specific knockout of th ...... ar to that in type 2 diabetes.
@en
Tissue-specific knockout of th ...... ar to that in type 2 diabetes.
@nl
P2093
P50
P1433
P1476
Tissue-specific knockout of th ...... ar to that in type 2 diabetes.
@en
P2093
Brüning JC
Kulkarni RN
P304
P356
10.1016/S0092-8674(00)80546-2
P407
P577
1999-02-01T00:00:00Z