Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
about
Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of AlkaloidsLessons from the past and charting the future of marine natural products drug discovery and chemical biologyComplexity generation during natural product biosynthesis using redox enzymesPictet-Spengler reaction-based biosynthetic machinery in fungi.Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis.Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking.Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly lineNonribosomal Peptide Synthesis-Principles and Prospects.Non-ribosomal propeptide precursor in nocardicin A biosynthesis predicted from adenylation domain specificity dependent on the MbtH family protein NocI.Proteomics guided discovery of flavopeptins: anti-proliferative aldehydes synthesized by a reductase domain-containing non-ribosomal peptide synthetase.Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads.Origin and variation of tunicate secondary metabolites.Merging chemical synthesis and biosynthesis: a new chapter in the total synthesis of natural products and natural product libraries.Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery.Biocatalytic reduction of carboxylic acids.Cyclization of polyketides and non-ribosomal peptides on and off their assembly lines.The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems.Oxidative Cyclization in Natural Product BiosynthesisBiomimetic Assembly Lines Producing Natural Product Analogs: Strategies from a Versatile Manifold to Skeletally Diverse Scaffolds.Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3.Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps.Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines.Discovery of McbB, an enzyme catalyzing the β-carboline skeleton construction in the marinacarboline biosynthetic pathway.Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.Catalysis of Extracellular Deamination by a FAD-Linked Oxidoreductase after Prodrug Maturation in the Biosynthesis of Saframycin A.Parallel lives of symbionts and hosts: chemical mutualism in marine animals.A natural prodrug activation mechanism in nonribosomal peptide synthesis.
P2860
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P2860
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
@en
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
@nl
type
label
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
@en
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
@nl
prefLabel
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
@en
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
@nl
P50
P356
P1476
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms
@en
P2093
Haruna Suda
Kento Koketsu
P2888
P304
P356
10.1038/NCHEMBIO.365
P577
2010-05-09T00:00:00Z