about
Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosisMolecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP)Role of ubiquitination in IGF-1 receptor signaling and degradation.Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor.Non-coding RNAs: the cancer genome dark matter that matters!Aberrant intracellular IGF-1R beta-subunit makes receptor knockout cells (IGF1R-/-) susceptible to oncogenic transformation.Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcoma.Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma.Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes.Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression.c-Kit-dependent growth of uveal melanoma cells: a potential therapeutic target?New picropodophyllin analogs via palladium-catalyzed allylic alkylation-Hiyama cross-coupling sequences.Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis.Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations.Malignant solitary fibrous tumour of the orbit.Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.Expression of insulin-like growth factor-1 receptor (IGF-1R) and p27Kip1 in melanocytic tumors: a potential regulatory role of IGF-1 pathway in distribution of p27Kip1 between different cyclinsInhibition of N-linked glycosylation down-regulates insulin-like growth factor-1 receptor at the cell surface and kills Ewing's sarcoma cells: therapeutic implicationsThe cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signalingThe coexistence of atypical intraductal hyperplasias with breast carcinomaReceptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implicationsInhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptorPrediction of BAP1 Expression in Uveal Melanoma Using Densely-Connected Deep Classification NetworksNon-Coding RNAs in IGF-1R Signaling Regulation: The Underlying Pathophysiological Link between Diabetes and CancerRuthenium-106 versus iodine-125 plaque brachytherapy of 571 choroidal melanomas with a thickness of ≥5.5 mmDecrypting noncoding RNA interactions, structures, and functional networksThe tale of a tail: The secret behind IGF-1R's oncogenic power
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
Leonard Girnita
@ast
Leonard Girnita
@en
Leonard Girnita
@es
Leonard Girnita
@nl
Leonard Girnita
@sl
type
label
Leonard Girnita
@ast
Leonard Girnita
@en
Leonard Girnita
@es
Leonard Girnita
@nl
Leonard Girnita
@sl
prefLabel
Leonard Girnita
@ast
Leonard Girnita
@en
Leonard Girnita
@es
Leonard Girnita
@nl
Leonard Girnita
@sl
P106
P1153
6603297841
P21
P31
P496
0000-0003-0280-9500