Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.
about
GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.Mechanisms of Hsp90 regulationReview: The HSP90 molecular chaperone-an enigmatic ATPaseSteroid Receptor-Associated Immunophilins: A Gateway to Steroid SignallingThe 'active life' of Hsp90 complexesCorresponding functional dynamics across the Hsp90 Chaperone family: insights from a multiscale analysis of MD simulationsThe hexameric structures of human heat shock protein 90Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants.A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p).Hsp90 is regulated by a switch point in the C-terminal domainSystematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 FunctionThe co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922Differential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study.A review of multi-domain and flexible molecular chaperones studies by small-angle X-ray scattering.Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure predictionExpression profiling and cross-species RNA interference (RNAi) of desiccation-induced transcripts in the anhydrobiotic nematode Aphelenchus avenae.Hydrogen-deuterium exchange strategy for delineation of contact sites in protein complexesHeat shock protein 90β stabilizes focal adhesion kinase and enhances cell migration and invasion in breast cancer cellsHeat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug.An in vivo photo-cross-linking approach reveals a homodimerization domain of Aha1 in S. cerevisiaeHsp90 C-terminal inhibitors exhibit antimigratory activity by disrupting the Hsp90α/Aha1 complex in PC3-MM2 cells.Post-translational modifications of Hsp90 and their contributions to chaperone regulationAdvances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment.Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond.Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylationFunction of cytosolic chaperones in Tom70-mediated mitochondrial import.Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC.S100A6 mediates nuclear translocation of Sgt1: a heat shock-regulated protein.Differences in conformational dynamics within the Hsp90 chaperone family reveal mechanistic insightsThe Mechanism of Hsp90 ATPase Stimulation by Aha1Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors.Localization of sites of interaction between p23 and Hsp90 in solution.Conserved conformational changes in the ATPase cycle of human Hsp90.Chemical shift assignments of CHU_1110: an AHSA1-like protein from Cytophaga hutchinsonii.Evidence for Hsp90 Co-chaperones in Regulating Hsp90 Function and Promoting Client Protein Folding.Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster.A chemical compound inhibiting the Aha1-Hsp90 chaperone complex.Functional and physical interaction between yeast Hsp90 and Hsp70.
P2860
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P2860
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Structural basis for recruitme ...... the Hsp90 chaperone machinery.
@en
type
label
Structural basis for recruitme ...... the Hsp90 chaperone machinery.
@en
prefLabel
Structural basis for recruitme ...... the Hsp90 chaperone machinery.
@en
P2093
P50
P356
P1433
P1476
Structural basis for recruitme ...... the Hsp90 chaperone machinery
@en
P2093
Barry Panaretou
Cara K Vaughan
Chunyan Liao
Ignacija Vlasic
Peter W Piper
S Mark Roe
P304
P356
10.1038/SJ.EMBOJ.7600141
P407
P577
2004-03-01T00:00:00Z