about
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeChaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complexActivation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sitesStructural basis for recruitment of BRCA2 by PALB2Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcsCrystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2.A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coliCrystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex.Crystal structure of a thwarted mismatch glycosylase DNA repair complexStructural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the -clampCrystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analoguesCrystal Structure of the Retinoblastoma Protein N Domain Provides Insight into Tumor Suppression, Ligand Interaction, and Holoprotein Architecture4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancerMolecular characterization of macbecin as an Hsp90 inhibitorStructural basis of the radicicol resistance displayed by a fungal hsp90Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulationInhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studiesStructural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity ReceptorsThe crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperoninsFeatures of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studiesThe Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3′ PhosphataseEngineering human MEK-1 for structural studies: A case study of combinatorial domain huntingThe BAH domain of Rsc2 is a histone H3 binding domainPhosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaksSelectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1The structural basis of specific base-excision repair by uracil-DNA glycosylaseCrystal structure of the beta-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostabilityChaperone ligand-discrimination by the TPR-domain protein Tah1.Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activityCrystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complexElectron microscopy studies on DNA recognition by DNA-PK.Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications.Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.A structural model for the retroviral proteases.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Laurence H Pearl
@ast
Laurence H Pearl
@en
Laurence H Pearl
@es
Laurence H Pearl
@nl
Laurence H Pearl
@sl
type
label
Laurence H Pearl
@ast
Laurence H Pearl
@en
Laurence H Pearl
@es
Laurence H Pearl
@nl
Laurence H Pearl
@sl
prefLabel
Laurence H Pearl
@ast
Laurence H Pearl
@en
Laurence H Pearl
@es
Laurence H Pearl
@nl
Laurence H Pearl
@sl
P106
P21
P31
P496
0000-0002-6910-1809