The application of the open pharmacological concepts triple store (Open PHACTS) to support drug discovery researchExperimental characterization of the human non-sequence-specific nucleic acid interactomeDiazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligandsOpen PHACTS: semantic interoperability for drug discoveryAnnotating Human P-Glycoprotein Bioassay DataHow Far Could We Go with Open Data - A Case Study for TRPV1 AntagonistsTaking Open Innovation to the Molecular Level - Strengths and LimitationsExploiting open data: a new era in pharmacoinformatics.Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives.A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities'Big data' in pharmaceutical science: challenges and opportunities.Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein.Lead identification for modulators of multidrug resistance based on in silico screening with a pharmacophoric feature model.Self-Organizing Maps for In Silico Screening and Data Visualization.In silico prediction models for blood-brain barrier permeation.A three-dimensional model for the substrate binding domain of the multidrug ATP binding cassette transporter LmrA.P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach.Interaction field based and hologram based QSAR analysis of propafenone-type modulators of multidrug resistance.Self-organizing maps for identification of new inhibitors of P-glycoprotein.Characterization of a novel class of antimalarials and its applicability to plasmodial target identification.Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.The N terminus of monoamine transporters is a lever required for the action of amphetaminesRandom mutagenesis of the prokaryotic peptide transporter YdgR identifies potential periplasmic gating residuesThe hERG potassium channel and drug trapping: insight from docking studies with propafenone derivatives.Coexistence of passive and carrier-mediated processes in drug transport.Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization.The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines.Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein.Applicability Domain ANalysis (ADAN): a robust method for assessing the reliability of drug property predictions.An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models.Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology modelMolecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors.Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer's disease.Insights into structure-activity relationship of GABAA receptor modulating coumarins and furanocoumarins.Medicinal chemistry in the era of big data.Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs.Inhibitors of p-glycoprotein--lead identification and optimisation.BCRP Inhibition: from Data Collection to Ligand-Based Modeling.Determination of the new MDR-modifier PFP 6 and its metabolites in human liver microsomes by high-performance liquid chromatography.
P50
Q19845588-246de72f-4095-fc65-2ba1-8dd4c4fa0f90Q21183985-DF3772DA-65EB-4E94-BBB7-C345D7F600F5Q24610075-F83E40A7-1664-446A-A36B-45D8B8CFA4AFQ27061937-E0267B1C-8CF7-44D9-8DF7-30A0D90BABA4Q27967903-77BCF518-17D4-4D3B-979E-9D9897E7CBACQ28681983-34C97B58-1FDD-4D18-B0C7-0A8D31FE60ACQ28710516-02A54854-B918-491B-90D1-D00004560F0FQ30486817-50A222A1-D037-4F11-AB0A-5E644C81D4B7Q30584510-FC9F48D9-3486-49C8-A717-FD9AD4F7AD7DQ30657759-F9324514-E664-45B9-9D69-A74AE35A4DE6Q30833246-7C9FAB19-4056-4564-B5C7-BF1AF678C74CQ31011332-E0E6F446-D470-4B3A-B13D-0CBEB01660A3Q31076351-13ECE05A-17DB-4E08-BA86-941BFD427D42Q31118091-7F513E7C-E51B-45D6-883C-DB0A050E99D4Q33203477-D70A8817-08E8-4090-BAEA-4780A315E0B4Q33205729-2F9EF413-6552-4EF3-BE4C-26C5A0372822Q33208416-D8C065C6-4A31-4B8F-8AE3-073D13FFCBE8Q33247339-A9270CBC-DBC7-4D58-8027-2A2274CD98A2Q33277897-8CE12912-BD02-47DE-B13D-9C29AE59DDF0Q33305231-450E3E24-3ACF-4EC2-ADA8-427BA500A808Q33408959-A0A55A0A-C3A9-4B45-8996-34EF54D3CFC9Q33796294-266EEA07-FF23-47CD-AC15-0D074D07E56EQ33894388-0ADD970A-42A1-4D8F-B6E4-E4DDF9041E3EQ34098002-0995F073-4C74-4A84-9170-E7A27FC65C3BQ34128770-0E2C8EFE-C690-421F-8B6E-87D0ABA91CEDQ34131906-645A13EF-24A2-4E03-A249-DC99BADB1084Q34137102-08BB941E-2F91-415E-A0C8-75F6F32DFDADQ34155954-652C89EC-4E45-4292-AD14-B63790120DC7Q34156111-A8A0B007-2977-4662-BDA9-62F3965BED8EQ34419726-A2CC7B35-CF44-4A99-8EAE-E1C9893F8C94Q34585478-1AE6976D-D79D-4EBC-B280-3B2BDC35D052Q34597890-69268959-5469-4B35-8B08-8A41A0E66952Q34661028-B6666464-8BF5-49EA-BDDC-E08C82B405E2Q35225960-78A3299C-E7D2-4FC9-BD03-4AE090FC68C7Q35388600-896A3AF4-4212-4BD9-8DF0-70008E850A05Q35701072-80D73C65-3605-41BF-A21F-AE884407085DQ35854911-B0AE9D6C-3A22-4032-B400-6AF4A489E456Q36048421-7FE19E5E-82DB-4C7D-9F6F-CBBED9AD8717Q36093462-234948E6-8CC2-436C-BC0B-1AA83789BABBQ36818020-D1B30FA1-947B-4DAA-B79A-471FF9E5AFD8
P50
description
Austrian medicinal chemist and Professor
@en
Oostenrijks onderzoeker (1962-)
@nl
investigador austriacu
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investigador austríaco
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österreichischer Forscher
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name
Gerhard Ecker
@ast
Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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type
label
Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
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altLabel
Gerhard F. Ecker
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prefLabel
Gerhard Ecker
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Gerhard Ecker
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Gerhard Ecker
@de
Gerhard Ecker
@en
Gerhard Ecker
@es
Gerhard Ecker
@fr
Gerhard Ecker
@ga
Gerhard Ecker
@nl
Gerhard Ecker
@sl
Gerhard Ecker
@sq
P106
P1006
P214
P227
P244
P1006
P1153
24794675100
P1416
P21
P213
0000 0001 0804 1892
P214
P227
P244
n2006181536
P2456
P27
P31
P496
0000-0003-4209-6883
P551
P569
1962-01-01T00:00:00Z
1962-10-01T00:00:00Z