Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model
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Monoamine transporters: insights from molecular dynamics simulationsDefining the blanks--pharmacochaperoning of SLC6 transporters and ABC transportersSpontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminusMapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular DynamicsA conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterTargeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter.Conformationally sensitive proximity of extracellular loops 2 and 4 of the γ-aminobutyric acid (GABA) transporter GAT-1 inferred from paired cysteine mutagenesisComputational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes.Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridgeRefinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding SiteFunctional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops.The Environment Shapes the Inner Vestibule of LeuT.Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine TransportersSLC Transporters: Structure, Function, and Drug Discovery.A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter.Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity.Identification of novel serotonin transporter compounds by virtual screening.Computational modeling of human dopamine transporter structures, mechanism and its interaction with HIV-1 transactivator of transcription.Impact of disruption of secondary binding site S2 on dopamine transporter function.Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters.Molecular Mechanism of Dopamine Transport by Human Dopamine Transporter.Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine BindingConformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290Zn(2+) reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorderFunctional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters.The role of human dopamine transporter in NeuroAIDS.A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter.Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism.Quantitative Assessment of the Energetics of Dopamine Translocation by Human Dopamine Transporter.Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization.SLC6 Transporter Folding Diseases and Pharmacochaperoning.Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter.Heterogeneities in Axonal Structure and Transporter Distribution Lower Dopamine Reuptake Efficiency.Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment.Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.
P2860
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P2860
Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Mutational analysis of the hig ...... ine transporter homology model
@ast
Mutational analysis of the hig ...... ine transporter homology model
@en
Mutational analysis of the hig ...... ine transporter homology model
@nl
type
label
Mutational analysis of the hig ...... ine transporter homology model
@ast
Mutational analysis of the hig ...... ine transporter homology model
@en
Mutational analysis of the hig ...... ine transporter homology model
@nl
prefLabel
Mutational analysis of the hig ...... ine transporter homology model
@ast
Mutational analysis of the hig ...... ine transporter homology model
@en
Mutational analysis of the hig ...... ine transporter homology model
@nl
P2093
P2860
P50
P1476
Mutational analysis of the hig ...... ine transporter homology model
@en
P2093
Oliver Kudlacek
Rene Weissensteiner
Therese R Montgomery
P2860
P304
P356
10.1371/JOURNAL.PCBI.1002909
P577
2013-02-21T00:00:00Z