about
Rrp6: Integrated roles in nuclear RNA metabolism and transcription terminationRtr1 Is a Dual Specificity Phosphatase That Dephosphorylates Tyr1 and Ser5 on the RNA Polymerase II CTDRPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylationRtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation.Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination.The SIRT2 deacetylase regulates autoacetylation of p300The exosome component Rrp6 is required for RNA polymerase II termination at specific targets of the Nrd1-Nab3 pathwayDelayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin.The interactome of the atypical phosphatase Rtr1 in Saccharomyces cerevisiaeThe role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress.Highly reproducible label free quantitative proteomic analysis of RNA polymerase complexes.Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin.Quantitative proteomics demonstrates that the RNA polymerase II subunits Rpb4 and Rpb7 dissociate during transcriptional elongation.Quantitative Analysis of Dynamic Protein Interactions during Transcription Reveals a Role for Casein Kinase II in Polymerase-associated Factor (PAF) Complex Phosphorylation and Regulation of Histone H2B MonoubiquitylationExpression and purification of functional human glycogen synthase-1 (hGYS1) in insect cellsPhosphatase Rtr1 Regulates Global Levels of Serine 5 RNA Polymerase II C-Terminal Domain Phosphorylation and Cotranscriptional Histone MethylationRegulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function.Examining the complexity of human RNA polymerase complexes using HaloTag technology coupled to label free quantitative proteomics.The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose.Glucose regulates insulin gene transcription by hyperacetylation of histone h4.Adenoviral gene transfer into beta-cell lines.A label free quantitative proteomic analysis of the Saccharomyces cerevisiae nucleusFunctional expression and analysis of the pancreatic transcription factor PDX-1 in yeast.Glucose-mediated phosphorylation converts the transcription factor Rgt1 from a repressor to an activator.Repression of transcription by Rgt1 in the absence of glucose requires Std1 and Mth1.Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1.Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.Statistical Analysis of Membrane Proteome Expression Changes inSaccharomycescerevisiaeProteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant SensitizationCasein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 InteractionCorrection: Baucum II, Anthony J. et al. Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization. Proteomes 2018, 6, 53RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription terminationHypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasisEndoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic β cell
P50
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description
academisch docent
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professor of biochemistry & molecular biology
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name
Amber L. Mosley
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Amber L. Mosley
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Amber L. Mosley
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Amber L. Mosley
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Amber L. Mosley
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Amber L. Mosley
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Amber L. Mosley
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Amber L. Mosley
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Amber_Mosley
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